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Found 139 with Last Name = 'tomita' and Initial = 't'
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490579(CHEMBL2337154)
Affinity DataIC50:  0.402nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490580(CHEMBL2337153)
Affinity DataIC50:  0.555nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490579(CHEMBL2337154)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490580(CHEMBL2337153)
Affinity DataIC50:  0.880nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490588(CHEMBL2336728)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50189039(4-(4-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulf...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490580(CHEMBL2337153)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of notch intracel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50189028(4-(4-(1-(4-chloro-N-(2,5-difluorophenyl)phenylsulf...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490588(CHEMBL2336728)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490578(CHEMBL2337566)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490578(CHEMBL2337566)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50189041(CHEMBL269580 | N-(5-(2-(4-(N-(1-(4-benzoyl-2-(3-(p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189036(4-chloro-N-phenyl-N-(1-(2-(3-(pyrrolidin-1-yl)prop...)
Affinity DataIC50:  10nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189031(CHEMBL266043 | N-(8-(2-(4-(N-(1-(4-benzoyl-2-(3-(p...)
Affinity DataIC50:  20nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490578(CHEMBL2337566)
Affinity DataIC50:  20nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of notch intracel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490579(CHEMBL2337154)
Affinity DataIC50:  41nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of notch intracel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16735(N-(2-{4-[(3R)-3-hydroxy-3-phenylpropyl]piperazin-1...)
Affinity DataIC50:  46nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-secretase subunit PEN-2(Homo sapiens (Human))
University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50143556((S)-2-{(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity of the compound against gamma-secretaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490580(CHEMBL2337153)
Affinity DataIC50:  68nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of Abeta42 secret...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16733(4-[1-(5-Amino)-pentyl]-1-{4-(phenyl)-2-[(naphthale...)
Affinity DataIC50:  68nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16734(N-(2-{4-[(3S)-3-hydroxy-3-phenylpropyl]piperazin-1...)
Affinity DataIC50:  69nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16736(N-[2-(4-benzoylpiperazin-1-yl)-5-phenylphenyl]naph...)
Affinity DataIC50:  79nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16727(N-{5-bromo-2-[4-(2-hydroxyethyl)piperazin-1-yl]phe...)
Affinity DataIC50:  79nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490579(CHEMBL2337154)
Affinity DataIC50:  84nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of IAbeta40 secre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490580(CHEMBL2337153)
Affinity DataIC50:  85nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of IAbeta40 secre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490579(CHEMBL2337154)
Affinity DataIC50:  86nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of Abeta42 secret...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16731(Naphthyl Compound, 5b | ethyl 2-{4-[2-(naphthalene...)
Affinity DataIC50:  90nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16732(1-{4-(Phenyl)-2-[(naphthalene-1-carbonyl)-amino]-p...)
Affinity DataIC50:  100nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16730(N-{2-[4-(2-hydroxyethyl)piperazin-1-yl]-5-phenylph...)
Affinity DataIC50:  110nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189045(CHEMBL373983 | N-(1-(4-benzoyl-2-(3-(pyrrolidin-1-...)
Affinity DataIC50:  130nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16749(Coumarin Compound, 11c | N-[2-(4-benzylpiperazin-1...)
Affinity DataIC50:  151nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM28922((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...)
Affinity DataIC50:  203nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490586(CHEMBL2337559)
Affinity DataIC50:  225nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490586(CHEMBL2337559)
Affinity DataIC50:  244nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta40 secretion by EL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16729(N-[5-phenyl-2-(piperazin-1-yl)phenyl]naphthalene-1...)
Affinity DataIC50:  300nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189043(4-fluoro-N-phenyl-N-(1-(2-(3-(pyrrolidin-1-yl)prop...)
Affinity DataIC50:  350nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189048(CHEMBL385166 | N-phenyl-N-(1-(2-(3-(pyrrolidin-1-y...)
Affinity DataIC50:  400nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM28922((2S)-N-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-h...)
Affinity DataIC50:  414nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in N2a NL/N cells coexpressing betaAPPNL and NotchdeltaE assessed as Abeta42 secretion by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189029(4-chloro-N-(2-methoxyphenyl)-N-(1-(2-(3-(pyrrolidi...)
Affinity DataIC50:  470nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189044(4-chloro-N-(2-chlorophenyl)-N-(1-(2-(3-(pyrrolidin...)
Affinity DataIC50:  490nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50186512(CHEMBL377810 | benzyl 6-benzyl-2-hydroxy-5-oxo-5,6...)
Affinity DataIC50:  500nMAssay Description:Inhibition of beta amyloid protein 40More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189037(4-chloro-N-(3-chlorophenyl)-N-(1-(2-(3-(pyrrolidin...)
Affinity DataIC50:  530nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189046(4-chloro-N-(3-methoxyphenyl)-N-(1-(2-(3-(pyrrolidi...)
Affinity DataIC50:  530nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16750(2,2,2-trifluoroacetic acid; 2-oxo-N-[5-phenyl-2-(p...)
Affinity DataIC50:  580nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Nagoya City University

Curated by ChEMBL
LigandPNGBDBM50490578(CHEMBL2337566)
Affinity DataIC50:  626nMAssay Description:Inhibition of gamma-secretase in human HEK293 cells expressing APPNL/NotchDeltaE/EGFP/UAS-firefly luciferase assessed as inhibition of Abeta42 secret...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16742(Coumarin Compound, 9e | N-{5-bromo-2-[4-(2-hydroxy...)
Affinity DataIC50:  630nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16741(2,2,2-trifluoroacetic acid; N-[5-bromo-2-(piperazi...)
Affinity DataIC50:  670nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50189026(CHEMBL211428 | N-phenyl-N-(1-(2-(3-(pyrrolidin-1-y...)
Affinity DataIC50:  690nMAssay Description:Inhibition of beta amyloid protein 40 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50186512(CHEMBL377810 | benzyl 6-benzyl-2-hydroxy-5-oxo-5,6...)
Affinity DataIC50:  700nMAssay Description:Inhibition of beta amyloid protein 42More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16740(CHEMBL206442 | Coumarin Compound, 9c | N-[2-(4-ben...)
Affinity DataIC50:  760nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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