TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human MTH1 assessed as hydrolysis of dGTP to dGMP and pyrophosphate after 15 mins by malachite green-based microplate reade...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human PARP1 by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Binding affinity to human ER alphaMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Md Anderson Cancer Center
Curated by ChEMBL
Md Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and meas...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human PARP1 after 3 hrs using [3H]NAD+ by scintillation proximity assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human PARP2 by trichloroacetic acid precipitation assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Irbm-Merck Research Laboratories Rome
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair