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Found 238 with Last Name = 'tsutsumi' and Initial = 's'
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of VEGFR2 in HUVEC assessed as reduction of VGF-stimulated cell proliferation after 5 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291167(1-((S)-Oxo-3-(R)-2-amino-1-phenyl-propyl)-pyrrolid...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50291175(((R)-1-Benzyl-2-{(S)-2-[(R)-4-guanidino-1-(thiazol...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291175(((R)-1-Benzyl-2-{(S)-2-[(R)-4-guanidino-1-(thiazol...)
Affinity DataIC50:  2nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291173(1-((S)-2-Amino-3-(R)-phenyl-propionyl)-azetidine-2...)
Affinity DataIC50:  3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50284127(4-Phenyl-1-{(S)-2-[(S)-2-(thiazole-2-carbonyl)-pyr...)
Affinity DataIC50:  3.10nMAssay Description:Compound was evaluated for the inhibition of Prolyl endopeptidase (PEP) from pig kidney using Z-Gly-Pro-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037610(1-{(S)-2-[(S)-2-(4,5-Dihydro-thiazole-2-carbonyl)-...)
Affinity DataIC50:  3.80nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037612(1-{(S)-2-[(S)-2-(Benzothiazole-2-carbonyl)-pyrroli...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50291167(1-((S)-Oxo-3-(R)-2-amino-1-phenyl-propyl)-pyrrolid...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50291163(4-Phenyl-1-{(S)-2-[(R)-2-(thiazole-2-carbonyl)-pyr...)
Affinity DataIC50:  4.40nMAssay Description:The compound was tested for the inhibitory activity against prolyl endo peptidase(PEP) enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50284127(4-Phenyl-1-{(S)-2-[(S)-2-(thiazole-2-carbonyl)-pyr...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50291168((S)-1-(4-Phenyl-butyryl)-pyrrolidine-2-carboxylic ...)
Affinity DataIC50:  5nMAssay Description:The compound was tested for the inhibitory activity against prolyl endo peptidase(PEP) enzymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037605((S)-2-[(S)-2-(Benzothiazole-2-carbonyl)-pyrrolidin...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037611(1-{(S)-2-[(S)-2-(Oxazolo[4,5-b]pyridine-2-carbonyl...)
Affinity DataIC50:  5.5nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037606(1-{(S)-2-[(S)-2-(Benzooxazole-2-carbonyl)-pyrrolid...)
Affinity DataIC50:  5.60nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037597(4-Phenyl-1-{(S)-2-[(S)-2-(thiazole-4-carbonyl)-pyr...)
Affinity DataIC50:  5.90nMAssay Description:Compound was evaluated for the inhibition of Prolyl endopeptidase (PEP) from pig kidney using Z-Gly-Pro-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037597(4-Phenyl-1-{(S)-2-[(S)-2-(thiazole-4-carbonyl)-pyr...)
Affinity DataIC50:  6.20nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509364(CHEMBL4463968)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037600(4-Phenyl-1-{(S)-2-[(S)-2-(pyridine-2-carbonyl)-pyr...)
Affinity DataIC50:  6.90nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM99471(US8497274, 32)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of N-terminal FLAG-tagged wild type BRAF (unknown origin) expressed in baculovirus system using GST-MEK1(K96R) as substrate after 20 minsMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037609(2-[2-(Thiazole-2-carbonyl)-pyrrolidine-1-carbonyl]...)
Affinity DataIC50:  8.5nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291166((R)-2-((R)-2-Amino-3-phenyl-propionylamino)-N-[(S)...)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50284126((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataIC50:  8.70nMAssay Description:Compound was evaluated for the inhibition of Prolyl endopeptidase (PEP) from pig kidney using Z-Gly-Pro-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037602(1-[(S)-1-(4-Phenyl-butyryl)-pyrrolidine-2-carbonyl...)
Affinity DataIC50:  8.70nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037604(1-{(S)-2-[(S)-2-(1H-Imidazole-2-carbonyl)-pyrrolid...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50291173(1-((S)-2-Amino-3-(R)-phenyl-propionyl)-azetidine-2...)
Affinity DataIC50:  9nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50509346(CHEMBL4470947)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50088247(CHEMBL303966 | Oxo-{(S)-1-[(S)-1-(4-phenyl-butyryl...)
Affinity DataIC50:  9.60nMAssay Description:Compound was evaluated for the inhibition of Prolyl endopeptidase (PEP) from pig kidney using Z-Gly-Pro-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401288(CHEMBL2204530)
Affinity DataIC50:  10nMAssay Description:Inhibition of VEGFR2 in HUVEC assessed as reduction of VGF-stimulated cell proliferation after 5 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037607(CHEMBL333638 | Oxo-{1-[(S)-1-(4-phenyl-butyryl)-py...)
Affinity DataIC50:  10.3nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401287(CHEMBL2204531)
Affinity DataIC50:  14nMAssay Description:Inhibition of VEGFR2 in HUVEC assessed as reduction of VGF-stimulated cell proliferation after 5 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509358(CHEMBL4534641)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509362(CHEMBL4483030)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50:  23nMAssay Description:Inhibition of c-RAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509354(CHEMBL4542665)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509356(CHEMBL4584730)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509360(CHEMBL4538356)
Affinity DataIC50:  38nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50:  43nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50:  45nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509353(CHEMBL4546647)
Affinity DataIC50:  48nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50509350(CHEMBL4441993)
Affinity DataIC50:  49nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50509351(CHEMBL4460077)
Affinity DataIC50:  53nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50037603(4-Phenyl-1-{(S)-2-[(S)-2-(pyrimidine-5-carbonyl)-p...)
Affinity DataIC50:  61nMAssay Description:In vitro inhibitory activity against prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401286(CHEMBL2204533)
Affinity DataIC50:  64nMAssay Description:Inhibition of VEGFR2 in HUVEC assessed as reduction of VGF-stimulated cell proliferation after 5 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM99471(US8497274, 32)
Affinity DataIC50:  66nMAssay Description:Inhibition of N-terminal His-6-tagged Aurora kinase B (unknown origin) expressed in baculovirus system after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50:  69nMAssay Description:Inhibition of wild type human BRAF (445 to 726) expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50:  86nMAssay Description:Inhibition of FGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509355(CHEMBL4551634)
Affinity DataIC50:  89nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401285(CHEMBL2204532)
Affinity DataIC50:  91nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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