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Found 86 with Last Name = 'tsuzaki' and Initial = 'y'
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50286290(CHEMBL4174314)
Affinity DataIC50:  0.497nMAssay Description:Inhibition of vitronectin binding to integrin alphaVbeta3 in HDF pretreated for 20 mins followed by vitronectin addition measured after 40 mins by cr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327443(N-{3-[(1R,5S)-6-ethyl-3-azabicyclo[3.1.0]hexan-6-y...)
Affinity DataIC50:  1.30nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327428( N-(3-{(1R,5S,6r)-3-[3-(4,4-difluoro-1-methoxycycl...)
Affinity DataIC50:  1.30nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327436(N-(3-{(1R,5S,6r)-3-[3-(1-ethoxy-4,4-difluorocycloh...)
Affinity DataIC50:  1.30nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327429(N-(3-{(1R,5S,6r)-3-[3-(4,4-difluoropiperidin-1-yl)...)
Affinity DataIC50:  1.40nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327423( N-(3-{(1R,5S,6r)-6-ethyl-3-[(2-hydroxy-2,3-dihydr...)
Affinity DataIC50:  1.5nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327426(N-(3-{(1R,5S,6r)-3-[3-(4,4-difluorocyclohexyl)prop...)
Affinity DataIC50:  1.5nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327427(N-(3-{(1R,5S,6r)-3-[3-(4,4-difluorocyclohexyl)prop...)
Affinity DataIC50:  1.60nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327437(N-(3-{(1R,5S,6r)-3-[3-(4,4-difluoropiperidin-1-yl)...)
Affinity DataIC50:  1.70nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327424(N-(3-{(1R,5S,6r)-6-ethyl-3-[(2-hydroxy-2,3-dihydro...)
Affinity DataIC50:  2nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50286289(CHEMBL4166054)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of vitronectin binding to human integrin alphaVbeta3 measured after 4 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327431(N-(3-{(1R,5S,6r)-3-[3-(3,3-difluoropyrrolidin-1-yl...)
Affinity DataIC50:  2.5nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327433(N-(3-{(1R,5S,6r)-6-ethyl-3-[(2-methoxy-2,3-dihydro...)
Affinity DataIC50:  2.80nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327430(N-(3-{(1R,5S,6r)-3-[3-(3,3-difluoropyrrolidin-1-yl...)
Affinity DataIC50:  2.90nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327438(N-(3-{(1R,5S,6r)-3-[3-(3,3-difluoropiperidin-1-yl)...)
Affinity DataIC50:  3.10nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327432(N-(3-{(1R,5S,6r)-6-ethyl-3-[(2-hydroxy-2,3-dihydro...)
Affinity DataIC50:  3.20nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327425(N-(3-{(1R,5S,6r)-6-ethyl-3-[(2-methoxy-2,3-dihydro...)
Affinity DataIC50:  3.60nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50286288(CHEMBL4159636)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of vitronectin binding to human integrin alphaVbeta3 measured after 4 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327435(N-(3-{(1R,5S,6r)-3-[(2-ethoxy-2,3-dihydro-1H-inden...)
Affinity DataIC50:  4.10nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327442(N-(3-{(1R,5S,6r)-3-[(5,6-difluoro-2-hydroxy-2,3-di...)
Affinity DataIC50:  4.10nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327441(N-(3-{(1R,5S,6r)-3-[(2-hydroxy-2,3-dihydro-1H-inde...)
Affinity DataIC50:  4.5nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327439(N-(3-{(1R,5S,6r)-3-[(2-hydroxy-2,3-dihydro-1H-inde...)
Affinity DataIC50:  5.40nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50237601(CHEMBL411941 | CycloRGDfV | [(2S,5R,8S,11S)-5-Benz...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of vitronectin binding to human integrin alphaVbeta3 measured after 4 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183273((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetIntegrase(Human immunodeficiency virus 1)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183275((S)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxy-3-met...)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50183274(6-(3-Chloro-2-fluorobenzyl)-1-(2-hydroxyethyl)-7-m...)
Affinity DataIC50:  9nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183274(6-(3-Chloro-2-fluorobenzyl)-1-(2-hydroxyethyl)-7-m...)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50237601(CHEMBL411941 | CycloRGDfV | [(2S,5R,8S,11S)-5-Benz...)
Affinity DataIC50:  11nMAssay Description:Inhibition of vitronectin binding to integrin alphaVbeta3 in HDF pretreated for 20 mins followed by vitronectin addition measured after 40 mins by cr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480416(CHEMBL549549)
Affinity DataIC50:  12nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327434(N-(3-{(1R,5S,6r)-6-ethyl-3-[(2-methoxy-2,3-dihydro...)
Affinity DataIC50:  12nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Sanwa Kagaku Kenkyusho

US Patent
LigandPNGBDBM327440(N-(3-{(1R,5S,6r)-3-[(2-methoxy-2,3-dihydro-1H-inde...)
Affinity DataIC50:  16nMAssay Description:The inhibition ratio of the test substance at the respective concentrations were calculated with setting the reaction value of the well to which DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480413(CHEMBL550893)
Affinity DataIC50:  21nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM23402(5-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(4-fluoropheny...)
Affinity DataIC50:  23nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50183276(6-(3-chloro-2-fluorobenzyl)-1-(2-hydroxyethyl)-4-o...)
Affinity DataIC50:  24nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50183276(6-(3-chloro-2-fluorobenzyl)-1-(2-hydroxyethyl)-4-o...)
Affinity DataIC50:  24nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480415(CHEMBL549546)
Affinity DataIC50:  25nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480439(CHEMBL562360)
Affinity DataIC50:  26nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480432(CHEMBL561099)
Affinity DataIC50:  31nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480441(CHEMBL558481)
Affinity DataIC50:  32nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480427(CHEMBL560439)
Affinity DataIC50:  34nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480411(CHEMBL563162)
Affinity DataIC50:  35nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480426(CHEMBL561100)
Affinity DataIC50:  38nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480442(CHEMBL549611)
Affinity DataIC50:  41nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480445(CHEMBL559903)
Affinity DataIC50:  43nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50235312(6-(3-chloro-2-fluorobenzyl)-4-oxo-1,4-dihydroquino...)
Affinity DataIC50:  44nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480435(CHEMBL550895)
Affinity DataIC50:  44nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480436(CHEMBL549750)
Affinity DataIC50:  50nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50476420(CHEMBL242883)
Affinity DataIC50:  50nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480410(CHEMBL551437)
Affinity DataIC50:  55nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Jt

Curated by ChEMBL
LigandPNGBDBM50480433(CHEMBL561827)
Affinity DataIC50:  65nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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