Found 112 with Last Name = 'turton' and Initial = 'r' TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of aurora-B (unknown origin) autophosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
3D Structure (crystal)TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of RON (unknown origin) autophosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of TAK1 in human TOV21G cells assessed as inhibition of JNK phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of ALK (unknown origin) autophosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 86nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of aurora B kinase in human HT-29 cells assessed as inhibition of histone H3 S10 phosphorylationMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of TAK1 in human HCT116 cells assessed as inhibition of TNF-alpha-stimulated JNK phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1(Homo sapiens (Human))
Osi Pharmaceuticals
Curated by ChEMBL
Osi Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of ALK autophosphorylation in human Karpas-299 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Inhibition of cMET (unknown origin) using biotinylated poly(Glu,Tyr) as substrate after 60 minsMore data for this Ligand-Target Pair
