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Found 738 with Last Name = 'van goethem' and Initial = 's'
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146972((S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1...)
Affinity DataKi:  0.0820nMAssay Description:Inhibition of DPP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350167(CHEMBL1814741)
Affinity DataKi:  6.5nMAssay Description:Competitive inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase IV(Porphyromonas gingivalis)
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataKi:  17nMAssay Description:Inhibition of Porphyromonas gingivalis N-terminal His-tagged DPP4 expressed in Escherichia coli using Gly-Pro-p-nitroanilide as substrate preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350175(CHEMBL1814749)
Affinity DataKi:  37nMAssay Description:Competitive inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146972((S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of DPP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146972((S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1...)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of DPP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50228403((R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-met...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50243690((2S,4S)-1-((S)-2-amino-6-(naphthalen-2-ylamino)hex...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of DPP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50382287(CHEMBL2024671)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant PREP expressed in Escherichia coli assessed as pNA release from Z-Gly-Pro-p-nitroanilide pre-incubated with enzyme fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50243649((2S,4S)-1-((2S,3R)-2-amino-3-methylpentanoyl)-4-az...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of DPP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350168(CHEMBL1814740)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350166(CHEMBL1814739)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350167(CHEMBL1814741)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50243649((2S,4S)-1-((2S,3R)-2-amino-3-methylpentanoyl)-4-az...)
Affinity DataIC50:  11nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50243690((2S,4S)-1-((S)-2-amino-6-(naphthalen-2-ylamino)hex...)
Affinity DataIC50:  13.8nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50:  14nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50243687(CHEMBL471747 | benzyl (S)-5-amino-6-((2S,4S)-4-azi...)
Affinity DataIC50:  21nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50050513((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human seminal plasma DPP4 assessed as pNA release from Gly-Pro-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50277245(CHEMBL4176189)
Affinity DataIC50:  22nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50243358((R)-3-((S)-2-amino-3-methylbutanoyl)thiazolidin-4-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50243689((2S,4S)-1-((S)-2-amino-6-(dinaphthalen-1-ylamino)h...)
Affinity DataIC50:  25nMAssay Description:Inhibition of DPP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50243650((2S,4S)-4-azido-1-((S)-2,6-diaminohexanoyl)pyrroli...)
Affinity DataIC50:  25nMAssay Description:Inhibition of DPP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350170(CHEMBL1814753)
Affinity DataIC50:  29nMAssay Description:Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350172(CHEMBL1814748)
Affinity DataIC50:  32nMAssay Description:Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50350187(CHEMBL1814759)
Affinity DataIC50:  33nMAssay Description:Inhibition of human seminal plasma DPP2 assessed as pNA release from Lys-Ala-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50243690((2S,4S)-1-((S)-2-amino-6-(naphthalen-2-ylamino)hex...)
Affinity DataIC50:  34nMAssay Description:Inhibition of DPP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50243648((2S,4S)-1-((2S,3S)-2-amino-3-methylpentanoyl)-4-az...)
Affinity DataIC50:  35nMAssay Description:Inhibition of DPP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50243646(CHEMBL471544 | benzyl (S)-5-amino-6-((S)-2-cyanopy...)
Affinity DataIC50:  35nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  40nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human seminal plasma DPP4 assessed as pNA release from Gly-Pro-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to s...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM11162((1R)-3-oxo-3-[3-(trifluoroethyl)-5,6-dihydro[1,2,4...)
Affinity DataIC50:  40nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50243187((S)-2-amino-1-(isoindolin-2-yl)-6-(naphthalen-2-yl...)
Affinity DataIC50:  43nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350175(CHEMBL1814749)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50243358((R)-3-((S)-2-amino-3-methylbutanoyl)thiazolidin-4-...)
Affinity DataIC50:  51nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50277245(CHEMBL4176189)
Affinity DataIC50:  51nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50350169(CHEMBL1814633 | US11096924, DASH-inhibitors 4160 (...)
Affinity DataIC50:  53nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350171(CHEMBL1814742)
Affinity DataIC50:  63nMAssay Description:Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Mus musculus (Mouse))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50050513((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Affinity DataIC50:  66nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells assessed as pNA release from Ala-Pro-p-nitroanilide pre-incubated with enzyme for 15 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50242855((2S,4S)-1-((S)-2-amino-6-(dinaphthalen-2-ylamino)h...)
Affinity DataIC50:  68nMAssay Description:Inhibition of DPP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50243129((2S,3R)-2-amino-1-(5-fluoroisoindolin-2-yl)-3-meth...)
Affinity DataIC50:  70nMAssay Description:Inhibition of DPP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50243650((2S,4S)-4-azido-1-((S)-2,6-diaminohexanoyl)pyrroli...)
Affinity DataIC50:  71nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50243648((2S,4S)-1-((2S,3S)-2-amino-3-methylpentanoyl)-4-az...)
Affinity DataIC50:  72nMAssay Description:Inhibition of DPP8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase IV(Porphyromonas gingivalis)
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50277239(CHEMBL4175831)
Affinity DataIC50:  79nMAssay Description:Inhibition of Porphyromonas gingivalis N-terminal His-tagged DPP4 expressed in Escherichia coli using Gly-Pro-p-nitroanilide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350174(CHEMBL1814745)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350178(CHEMBL1814747)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50243689((2S,4S)-1-((S)-2-amino-6-(dinaphthalen-1-ylamino)h...)
Affinity DataIC50:  82nMAssay Description:Inhibition of DPP9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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