Compile Data Set for Download or QSAR
maximum 50k data
Found 366 with Last Name = 'vicker' and Initial = 'n'
Target11-beta-hydroxysteroid dehydrogenase type 2(Rattus norvegicus)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50147505((2S,4aS,6aS,6bR,10S,12aS,14bR)-10-Hydroxy-2,4a,6a,...)
Affinity DataIC50:  0.00400nMAssay Description:Percent inhibition against 11-beta-hydroxysteroid dehydrogenase 2 of wistar rat kidney at 10 microM was determined using [3H]-cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041849(3-(Bicyclo[2.2.1]hept-2-yloxy)-N-(3,5-dichloro-pyr...)
Affinity DataIC50:  1nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041849(3-(Bicyclo[2.2.1]hept-2-yloxy)-N-(3,5-dichloro-pyr...)
Affinity DataIC50:  1nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041853(3-Cyclopentyloxy-N-(3,5-dichloro-1-oxy-pyridin-4-y...)
Affinity DataIC50:  2nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041831(3-Cyclopentyloxy-N-(3,5-dibromo-pyridin-4-yl)-4-me...)
Affinity DataIC50:  7nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50:  8nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041846(3-Butoxy-N-(3,5-dichloro-pyridin-4-yl)-4-methoxy-b...)
Affinity DataIC50:  8nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50134329(CHEMBL122708 | Sulfamic acid (11R,12S,15S,16S)-13-...)
Affinity DataIC50:  9nMAssay Description:Compound was tested for inhibition of human carbonic anhydrase (hCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041886(3-(Bicyclo[2.2.1]hept-2-yloxy)-N-(2,6-dichloro-phe...)
Affinity DataIC50:  10nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataIC50:  14nMAssay Description:Compound was tested for inhibition of human carbonic anhydrase (hCA II)More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM13423(CHEMBL167368 | STX 118 | [3-(2-cyclohexylethyl)-4-...)
Affinity DataIC50:  15nMAssay Description:Compound was tested for inhibition of human carbonic anhydrase (hCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041847(CHEMBL295976 | N-(3-Chloro-pyridin-4-yl)-3-cyclope...)
Affinity DataIC50:  16nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50:  17nMAssay Description:Compound was tested for inhibition of human carbonic anhydrase (hCA II)More data for this Ligand-Target Pair
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041875(3-Cyclopentyloxy-N-(3,5-dichloro-2,6-difluoro-pyri...)
Affinity DataIC50:  20nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM11637((15S)-15-methyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{...)
Affinity DataIC50:  20nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041838(3-(cyclopentyloxy)-N-(2,6-dichlorophenyl)-4-methox...)
Affinity DataIC50:  23nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataIC50:  25nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM13058(6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-...)
Affinity DataIC50:  25nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50237104(2-((8R,9S,13S,14S,16R)-2-ethyl-3-hydroxy-13-methyl...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against 17 beta hydroxysteroid dehydrogenase type 1 in T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50237104(2-((8R,9S,13S,14S,16R)-2-ethyl-3-hydroxy-13-methyl...)
Affinity DataIC50:  27nMAssay Description:Inhibition of 17beta-HSD1 expressed in intact human T47D cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13424((15S)-14-hydroxy-4-methoxy-15-methyltetracyclo[8.7...)
Affinity DataIC50:  34nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041869(3-Cyclopentyloxy-N-(3,5-dimethyl-pyridin-4-yl)-4-m...)
Affinity DataIC50:  35nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM13057(CHEMBL417656 | Compound 9 | Cyclic Sulfate Analogu...)
Affinity DataIC50:  36nMAssay Description:Compound was tested for inhibition of human carbonic anhydrase (hCA II)More data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50370656(CHEMBL1627749)
Affinity DataIC50:  37nMAssay Description:Inhibitory activity against 17 beta hydroxysteroid dehydrogenase type 1 in T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50370656(CHEMBL1627749)
Affinity DataIC50:  37nMAssay Description:Inhibition of 17-beta HSD1 in T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13426((15S)-4-methoxy-15-methyl-5-(sulfamoyloxy)tetracyc...)
Affinity DataIC50:  39nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM11637((15S)-15-methyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{...)
Affinity DataIC50:  42nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140820(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  43nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteryl-sulfatase(Homo sapiens (Human))
St. Mary'S Hospital

LigandPNGBDBM13423(CHEMBL167368 | STX 118 | [3-(2-cyclohexylethyl)-4-...)
Affinity DataIC50:  46nMAssay Description:The extent of in vitro inhibition of sulfatase activities was assessed using intact monolayers of JEG-3 cells. Sulfatase activity was measured using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041824(3-Cyclohexyloxy-N-(3,5-dichloro-pyridin-4-yl)-4-me...)
Affinity DataIC50:  50nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM13423(CHEMBL167368 | STX 118 | [3-(2-cyclohexylethyl)-4-...)
Affinity DataIC50:  59nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140825(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  61nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041879(3-Butoxy-N-(3,5-dibromo-pyridin-4-yl)-4-methoxy-be...)
Affinity DataIC50:  70nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041844(3-(cyclopentyloxy)-N-(2,6-difluorophenyl)-4-methox...)
Affinity DataIC50:  70nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140803(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  76nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041877(3-Cyclopentyloxy-4-methoxy-N-(2,3,5-trifluoro-pyri...)
Affinity DataIC50:  85nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM13419((15S)-15-methyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{...)
Affinity DataIC50:  92nMpH: 7.8 T: 2°CAssay Description:The in vitro inhibition of carbonic anhydrase was assessed by a colorimetric assay. Carbonic anhydrase-catalysed hydrolysis of p-nitrophenyl acetate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041854(CHEMBL294949 | N-(2-Chloro-6-methyl-phenyl)-3-cycl...)
Affinity DataIC50:  100nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041826(3-Cyclopentyloxy-N-(2,6-dimethyl-phenyl)-4-methoxy...)
Affinity DataIC50:  100nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041873(CHEMBL47286 | N-(3-Chloro-2,5,6-trifluoro-pyridin-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041866(CHEMBL48017 | N-(3,5-Dichloro-pyridin-4-yl)-3,4-di...)
Affinity DataIC50:  100nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140804(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  105nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50172493((13S)-3-hydroxy-16-(hydroxymethylene)-13-methyl-7,...)
Affinity DataIC50:  110nMAssay Description:Inhibition of 17-beta-hydroxysteroid dehydrogenase type 1 expressed in T47D human breast cancer cells using 2 nM [3H]estroneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50172493((13S)-3-hydroxy-16-(hydroxymethylene)-13-methyl-7,...)
Affinity DataIC50:  110nMAssay Description:Inhibition of 17-beta HSD1 in T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50394437(CHEMBL2159084)
Affinity DataIC50:  114nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50394435(CHEMBL2159638)
Affinity DataIC50:  118nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041856(CHEMBL48048 | N-(4-Chloro-pyridin-3-yl)-3-cyclopen...)
Affinity DataIC50:  120nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140798(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50394439(CHEMBL2159082)
Affinity DataIC50:  125nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 366 total ) | Next | Last >>
Jump to: