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Found 70 with Last Name = 'watanabe' and Initial = 'ka'
TargetDihydrofolate reductase(Mus musculus (Mouse))
Cornell University

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataKi:  0nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of L-1210 cellsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Cornell University

Curated by ChEMBL
LigandPNGBDBM50016326(2-{4-[(2,4-Diamino-5-methyl-pyrido[2,3-d]pyrimidin...)
Affinity DataKi:  0nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of L-1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Cornell University

Curated by ChEMBL
LigandPNGBDBM50023681(2-{4-[(2,4-Diamino-5,7-dimethyl-pyrido[2,3-d]pyrim...)
Affinity DataKi:  0.00200nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of L-1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Cornell University

Curated by ChEMBL
LigandPNGBDBM50023682(2-{4-[(2,4-Diamino-5-methyl-7-phenyl-pyrido[2,3-d]...)
Affinity DataKi: >0.00400nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of L-1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Cornell University

Curated by ChEMBL
LigandPNGBDBM50023684(2-{4-[(2,4-Diamino-7-methyl-5-phenyl-pyrido[2,3-d]...)
Affinity DataKi: >0.00400nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of L-1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Cornell University

Curated by ChEMBL
LigandPNGBDBM50023683(2-{4-[(2,4-Diamino-7-methyl-pyrido[2,3-d]pyrimidin...)
Affinity DataKi: >0.00400nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of L-1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Cornell University

Curated by ChEMBL
LigandPNGBDBM50023680(2-{4-[(2,4-Diamino-7-phenyl-pyrido[2,3-d]pyrimidin...)
Affinity DataKi: >0.00400nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) of L-1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlcohol dehydrogenase E/S chain(Equus caballus)
Cornell University

Curated by ChEMBL
LigandPNGBDBM50368629(CHEMBL2368671)
Affinity DataKi:  1.10nMAssay Description:Inhibition of horse liver alcohol dehydrogenase enzyme by Non-competitive inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlcohol dehydrogenase 1A(Homo sapiens (Human))
University Of Rochester Medical Center

Curated by ChEMBL
LigandPNGBDBM50368954(CHEMBL610377)
Affinity DataKi:  2nMAssay Description:Apparent inhibition constant against mammalian liver alcohol dehydrogenase (ADH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlcohol dehydrogenase 1A(Homo sapiens (Human))
University Of Rochester Medical Center

Curated by ChEMBL
LigandPNGBDBM50368954(CHEMBL610377)
Affinity DataKi:  4nMAssay Description:Inhibition constant against mammalian liver alcohol dehydrogenase (ADH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19264((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Affinity DataKi:  6nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II isoform); Range is 6-10 nMMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19264((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Affinity DataKi:  10nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II)More data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19264((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Affinity DataKi:  33nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I isoform); Range is 33-37 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19264((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Affinity DataKi:  40nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50367389(CHEMBL605602)
Affinity DataKi:  110nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50367389(CHEMBL605602)
Affinity DataKi:  110nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370187(CHEMBL608195)
Affinity DataKi:  290nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50369419(CHEMBL610421)
Affinity DataKi:  300nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II isoform)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50369298(CHEMBL605601)
Affinity DataKi:  300nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50369298(CHEMBL605601)
Affinity DataKi:  300nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370187(CHEMBL608195)
Affinity DataKi:  330nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50108912(CHEMBL162782 | {Hydroxy-[2-(4-hydroxy-6-methoxy-7-...)
Affinity DataKi:  400nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlcohol dehydrogenase 1A(Homo sapiens (Human))
University Of Rochester Medical Center

Curated by ChEMBL
LigandPNGBDBM50192456([(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataKi:  400nMAssay Description:Inhibition constant against mammalian liver alcohol dehydrogenase (ADH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50108910(CHEMBL348359 | {Hydroxy-[2-(4-hydroxy-6-methoxy-7-...)
Affinity DataKi:  470nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370188(CHEMBL608194)
Affinity DataKi:  660nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50108912(CHEMBL162782 | {Hydroxy-[2-(4-hydroxy-6-methoxy-7-...)
Affinity DataKi:  890nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370188(CHEMBL608194)
Affinity DataKi:  950nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2 (IMPDH type II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50108910(CHEMBL348359 | {Hydroxy-[2-(4-hydroxy-6-methoxy-7-...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate dehydrogenase 1, mitochondrial(Bos taurus)
University Of Rochester Medical Center

Curated by ChEMBL
LigandPNGBDBM50192456([(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihyd...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition constant against mammalian glutamate dehydrogenase (GDH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate dehydrogenase 1, mitochondrial(Bos taurus)
University Of Rochester Medical Center

Curated by ChEMBL
LigandPNGBDBM50368629(CHEMBL2368671)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of bovine glutamate dehydrogenase (GDH) enzyme by competitive inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate dehydrogenase 1, mitochondrial(Bos taurus)
University Of Rochester Medical Center

Curated by ChEMBL
LigandPNGBDBM50368954(CHEMBL610377)
Affinity DataKi:  1.50E+4nMAssay Description:Apparent inhibition constant against mammalian glutamate dehydrogenase (GDH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlcohol dehydrogenase E/S chain(Equus caballus)
Cornell University

Curated by ChEMBL
LigandPNGBDBM50230758(CHEMBL3144046)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibition of horse liver alcohol dehydrogenase enzyme by non-competitive inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlcohol dehydrogenase 1A(Homo sapiens (Human))
University Of Rochester Medical Center

Curated by ChEMBL
LigandPNGBDBM50368955(CHEMBL1235132)
Affinity DataKi:  2.10E+4nMAssay Description:Apparent inhibition constant against mammalian liver alcohol dehydrogenase (ADH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate dehydrogenase 1, mitochondrial(Bos taurus)
University Of Rochester Medical Center

Curated by ChEMBL
LigandPNGBDBM50368955(CHEMBL1235132)
Affinity DataKi:  2.10E+4nMAssay Description:Inhibition constant against mammalian glutamate dehydrogenase (GDH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
University Of Rochester Medical Center

Curated by ChEMBL
LigandPNGBDBM50368954(CHEMBL610377)
Affinity DataKi:  1.88E+5nMAssay Description:Apparent inhibition constant against mammalian lactate dehydrogenase (LDH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50470378(CHEMBL108283)
Affinity DataIC50:  20nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50470365(CHEMBL326664)
Affinity DataIC50:  45nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50470374(CHEMBL322325)
Affinity DataIC50:  54nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50470371(CHEMBL325543)
Affinity DataIC50:  63nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50421763(CHEMBL2364562)
Affinity DataIC50:  90nMAssay Description:The compound was assayed to determine the inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50367389(CHEMBL605602)
Affinity DataIC50:  110nMAssay Description:The compound was assayed to determine the inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50470361(CHEMBL108404)
Affinity DataIC50:  116nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50470369(CHEMBL325588)
Affinity DataIC50:  226nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50369298(CHEMBL605601)
Affinity DataIC50:  300nMAssay Description:The compound was assayed to determine the inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50369299(CHEMBL605181)
Affinity DataIC50:  700nMAssay Description:The compound was assayed to determine the inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50369297(CHEMBL603794)
Affinity DataIC50:  800nMAssay Description:The compound was assayed to determine the inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Codon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50369293(CHEMBL608605)
Affinity DataIC50:  800nMAssay Description:The compound was assayed to determine the inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50470357(CHEMBL321473)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM87351(Amsacrine hydrochloride | CHEMBL43 | MLS002153376 ...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Sloan-Kettering Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50470362(CHEMBL444329)
Affinity DataIC50: <1.00E+3nMAssay Description:In vitro 50% inhibition of topoisomerase II mediated k-DNA decatenationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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