Compile Data Set for Download or QSAR
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Found 203 with Last Name = 'weiser' and Initial = 'a'
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246460(3-(6-(2-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246459(3-(6-(2-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-2...)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50324574((R)-6-Methoxy-N-(2-((1-methylpiperidin-4-yl)methox...)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50324585(CHEMBL1215022 | N-(4-(1H-Pyrazol-4-yl)phenyl)-2-am...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2 [1-543,T431N](Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM25472(CHEMBL519123 | N-[4-(1H-pyrazol-4-yl)phenyl]-2,3-d...)
Affinity DataIC50:  1.5nMpH: 7.0 T: 2°CAssay Description:Assays were performed using the STK2 kinase system from Cisbio. Reaction mixture containing STK2 substrate, ATP and test compound was added to the we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256384(6-chloro-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50324604(CHEMBL1215021 | N-(4-(1H-Pyrazol-4-yl)phenyl)-2-am...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246455(2-(3,4-dihydro-2H-chromen-3-yl)-6-(pyridin-4-yl)-1...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50245868(4-(2-(6-methoxy-3,4-dihydro-2H-chromen-3-yl)benzo[...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256436(CHEMBL481735 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246409(CHEMBL455658 | N-(4-(1H-pyrazol-4-yl)phenyl)-3,4-d...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256067(CHEMBL481685 | N3-(4-(1H-pyrazol-4-yl)phenyl)-N6-(...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246458(4-(2-(6-methoxy-3,4-dihydro-2H-chromen-3-yl)-3H-be...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM25472(CHEMBL519123 | N-[4-(1H-pyrazol-4-yl)phenyl]-2,3-d...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256322(CHEMBL482336 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50324592((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256383(CHEMBL481545 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246409(CHEMBL455658 | N-(4-(1H-pyrazol-4-yl)phenyl)-3,4-d...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256166(CHEMBL475601 | N-(4-(1H-pyrazol-4-yl)phenyl)-6-met...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256382(6-fluoro-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256069(6-methoxy-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)c...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256111(CHEMBL480586 | N-(2-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256068(6-methoxy-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)c...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256385(6-chloro-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256163(CHEMBL474425 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50324602((R)-6-Methoxy-N-(2-(1-methylpiperidin-4-yloxy)-4-(...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50324605((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2 [1-543,T431N](Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM25474(JMC516642 Compound 5 | N-{2-[2-(dimethylamino)etho...)
Affinity DataIC50:  3.20nMpH: 7.0 T: 2°CAssay Description:Assays were performed using the STK2 kinase system from Cisbio. Reaction mixture containing STK2 substrate, ATP and test compound was added to the we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2 [1-543,T431N](Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM25473(N-[2-methoxy-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydr...)
Affinity DataIC50:  3.30nMpH: 7.0 T: 2°CAssay Description:Assays were performed using the STK2 kinase system from Cisbio. Reaction mixture containing STK2 substrate, ATP and test compound was added to the we...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256435(CHEMBL519269 | N-(2-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256112(CHEMBL519101 | N-(2-fluoro-4-(1H-pyrazol-4-yl)phen...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256113(CHEMBL480746 | N-(3,5-difluoro-4-(1H-pyrazol-4-yl)...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256223(CHEMBL475612 | N-(4-(1H-pyrazol-4-yl)phenyl)-6-flu...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256110(CHEMBL480585 | N-(3-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50324590((R)-N-(2-(4-(Dimethylamino)-4-oxobutylthio)-4-(3-m...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256224(CHEMBL475613 | N-(4-(1H-pyrazol-4-yl)phenyl)-6-chl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256114(CHEMBL481731 | N-(5-fluoro-2-methoxy-4-(1H-pyrazol...)
Affinity DataIC50:  5nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256386(6-chloro-N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyra...)
Affinity DataIC50:  5nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256163(CHEMBL474425 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256069(6-methoxy-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)c...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256382(6-fluoro-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256383(CHEMBL481545 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256322(CHEMBL482336 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256323(6-fluoro-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256386(6-chloro-N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyra...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256111(CHEMBL480586 | N-(2-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256114(CHEMBL481731 | N-(5-fluoro-2-methoxy-4-(1H-pyrazol...)
Affinity DataIC50:  6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50256068(6-methoxy-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)c...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute-Florida

Curated by ChEMBL
LigandPNGBDBM50246461(4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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