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Found 620 with Last Name = 'white' and Initial = 'n'
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214682(1-{4-[(1S)-2-(1-amino-3-methylbutyl)-4-trifluorome...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214688(1-{4-[(1R)-2-(amino-3-methylbutyl)-6-fluorophenyl]...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214704(1-{4-[(1S)-2-(amino-3-methylbutyl)-4-fluorophenyl]...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214695(1-{4-[(1S)-2-(1-amino-3-methylbutyl)-4-trifluorome...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214689(1-{4-[(1S)-2-(1-amino-3-methylbutyl)-4-trifluorome...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214703(1-{4-[(1R)-2-(amino-3-methylbutyl)-6-fluorophenyl]...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214679(1-{4-[(1S)-2-(amino-3-methylbutyl)-6-trifluorometh...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329367(2-(3-cyanobenzamido)-N-isopropyl-3-(3-methoxypropy...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]SCH58261 from human recombinant A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329364(2-(3-cyanobenzamido)-N,N-diethyl-1-(3-methoxypropy...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]SCH58261 from human recombinant A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214691(1-{4-[(1S)-2-(1-amino-3-methylbutyl)-6-trifluorome...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214700(1-{4-[(1S)-2-(1-amino-3-methylbutyl)-6-fluoropheny...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329367(2-(3-cyanobenzamido)-N-isopropyl-3-(3-methoxypropy...)
Affinity DataKi:  4.30nMAssay Description:Antagonist activity at rat A2A receptor by cAMP functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214696(1-((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trif...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214681(1-[(R)-2-{4-[(1S)-2-(1-amino-3-methylbutyl)-4-trif...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50160531(CHEMBL183799 | Quinoline-3-carboxylic acid [(R)-1-...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity towards human melanocortin 4 receptor expressed in HEK 293 cells using [125I]NDP-MSHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214685(1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifl...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity to C57BL/6J mouse MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190994((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-methylph...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214692(1-{4-[(1R)-2-(1-amino-3-methylbutyl)-6-fluoropheny...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50160546(CHEMBL182277 | N-[(R)-1-(4-Chloro-benzyl)-2-oxo-2-...)
Affinity DataKi:  6.30nMAssay Description:Binding affinity towards human melanocortin 4 receptor expressed in HEK 293 cells using [125I]NDP-MSHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329348((R)-3-cyano-N-(3-(3-methoxypropyl)-6-(2-methylpipe...)
Affinity DataKi:  6.40nMAssay Description:Antagonist activity at rat A2A receptor by cAMP functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152799((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152799((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity towards human melanocortin 4 receptor expressed in HEK 293 cells using [125I]NDP-MSHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214701(1-((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)phenyl)p...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190978((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-(trifluo...)
Affinity DataKi:  6.5nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214698(1-{4-[(1R)-2-(1-amino-3-methylbutyl)-6-fluoropheny...)
Affinity DataKi:  7.10nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214684(1-{4-[(1S)-2-(1-amino-3-methylbutyl)-6-fluoropheny...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329348((R)-3-cyano-N-(3-(3-methoxypropyl)-6-(2-methylpipe...)
Affinity DataKi:  7.70nMAssay Description:Displacement of [3H]SCH58261 from human recombinant A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50191013((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-methylph...)
Affinity DataKi:  8.10nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214699(1-[(S)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifl...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190987((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)-4-methylph...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50191008(1-(4-(2-((S)-1-amino-3-methylbutyl)-4-chlorophenyl...)
Affinity DataKi:  9.10nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214685(1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifl...)
Affinity DataKi:  9.10nMAssay Description:Binding affinity to rat MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329342(3-cyano-N-(3-(3-methoxypropyl)-6-(piperidine-1-car...)
Affinity DataKi:  9.60nMAssay Description:Displacement of [3H]SCH58261 from human recombinant A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214697((1S)-(2-{4-[(2R)-(2-oxo-1-pyrrolidinyl)-3-(2,4-dic...)
Affinity DataKi:  9.70nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50160544(2-Amino-1,2,3,4-tetrahydro-naphthalene-2-carboxyli...)
Affinity DataKi:  10nMAssay Description:Binding affinity towards human melanocortin 4 receptor expressed in HEK 293 cells using [125I]NDP-MSHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214702(1-{4-[(1R)-2-(amino-3-methylbutyl)-4-fluorophenyl]...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  10nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152800(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329349((S)-3-cyano-N-(3-(3-methoxypropyl)-6-(2-methylpipe...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]SCH58261 from human recombinant A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50174251((S)-N-((R)-3-(4-chlorophenyl)-1-oxo-1-(4-(1-((2-ph...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214685(1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifl...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152808((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards human melanocortin 4 receptor expressed in HEK 293 cells using [125I]NDP-MSHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152807((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329347(2-(3-cyanobenzamido)-N-isopropyl-3-(3-methoxypropy...)
Affinity DataKi:  12nMAssay Description:Antagonist activity at rat A2A receptor by cAMP functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329366(2-(3-cyanobenzamido)-N-ethyl-3-(3-methoxypropyl)-N...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]SCH58261 from human recombinant A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190972((R)-1-(4-(2-((S)-1-amino-3-methylbutyl)phenyl)pipe...)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152795(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataKi:  13nMAssay Description:Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329347(2-(3-cyanobenzamido)-N-isopropyl-3-(3-methoxypropy...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]SCH58261 from human recombinant A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189188(3-amino-N-((1S)-1-(2-(4-(3-(2,4-dichlorophenyl)pro...)
Affinity DataKi:  13nMAssay Description:Activity at MC4R assessed as inhibition of alpha-MSH-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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