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Found 253 with Last Name = 'wickramasinghe' and Initial = 'd'
TargetSmoothened homolog(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50:  0.00200nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001577(CHEMBL3237712)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001541(CHEMBL3237706)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320340((R)-(3-methyl-4-(4-p-tolylphthalazin-1-yl)piperazi...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50179795(CHEMBL382690 | PVKRRL-(3-Cl)F-NH2)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001576(CHEMBL3237711)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001583(CHEMBL3237718)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320341((R)-(4-(4-(4-chlorophenyl)phthalazin-1-yl)-3-methy...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323147((R)-(3-methyl-4-(1-(4-(trifluoromethyl)phenyl)pyri...)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001576(CHEMBL3237711)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001543(CHEMBL3237708)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM112464(US8623885, 5)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001537(CHEMBL3237702 | US8841312, 55)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50323147((R)-(3-methyl-4-(1-(4-(trifluoromethyl)phenyl)pyri...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001539(CHEMBL3237704 | US8841312, 204)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001544(CHEMBL3237709)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001543(CHEMBL3237708)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001536(CHEMBL3237451 | US8841312, 23)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001545(CHEMBL3237710)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001537(CHEMBL3237702 | US8841312, 55)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001584(CHEMBL3237442 | US8841312, 1)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001538(CHEMBL3237703)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001542(CHEMBL3237707)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001544(CHEMBL3237709)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320358((R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320358((R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320339((R)-(4-(4-(4-cyclopropylphenyl)phthalazin-1-yl)-3-...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320336((R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320336((R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl...)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50323146((R)-(3-methyl-4-(1-phenylpyrido[3,4-d]pyridazin-4-...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM112464(US8623885, 5)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001582(CHEMBL3237717)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001579(CHEMBL3237714)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001578(CHEMBL3237713)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001577(CHEMBL3237712)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001541(CHEMBL3237706)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001540(CHEMBL3237705)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001585(CHEMBL3237443 | US8841312, 57)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001582(CHEMBL3237717)
Affinity DataIC50:  3nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001540(CHEMBL3237705)
Affinity DataIC50:  3nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001535(CHEMBL3237450)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320335((R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthala...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320345((S)-(2-methyl-4-(4-p-tolylphthalazin-1-yl)piperazi...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50323132((R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthala...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320342((S)-(2-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001545(CHEMBL3237710)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001581(CHEMBL3237716)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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