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Found 316 with Last Name = 'willardsen' and Initial = 'ja'
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM81396(GMX1778)
Affinity DataIC50:  0.0700nMAssay Description:In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM81395(APO-866)
Affinity DataIC50:  0.140nMAssay Description:In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.More data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM81393(MPI-0479883)
Affinity DataIC50:  0.170nMAssay Description:In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50117198(4-{[7-Chloro-3-methyl-2-(4-methyl-piperazin-1-ylme...)
Affinity DataIC50:  0.230nMAssay Description:In vitro inhibition assay using human nampt, NMN adenylytransferase (nmant1)and UDP-glucose dehdryogenase (ugdh) genes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347432(CHEMBL1801863)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50117198(4-{[7-Chloro-3-methyl-2-(4-methyl-piperazin-1-ylme...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347433(CHEMBL1801864)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347427(CHEMBL1801934)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347431(CHEMBL1801862)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348075(CHEMBL1800705)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347394(CHEMBL1801566)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347407(CHEMBL1801561)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347415(CHEMBL1801552)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347391(CHEMBL1801563)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347406(CHEMBL1801562)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347395(CHEMBL1801567)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347401(CHEMBL1801855)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347441(CHEMBL568305)
Affinity DataIC50:  3nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-mediated decrease in cellular NAD levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347424(CHEMBL1801937)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348068(CHEMBL1800516)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347430(CHEMBL1801861)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347408(CHEMBL1801560)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347442(CHEMBL1801559)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50042034((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
Affinity DataIC50:  8nMAssay Description:Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assayMore data for this Ligand-Target Pair
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172214(6-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348065(CHEMBL1800513)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50191935(CHEMBL1761718)
Affinity DataIC50:  8.90nMAssay Description:Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348085(CHEMBL1800715)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172213(6-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347426(CHEMBL1801935)
Affinity DataIC50:  11nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347398(CHEMBL1801570)
Affinity DataIC50:  12nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347429(CHEMBL1801860)
Affinity DataIC50:  12nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347393(CHEMBL1801565)
Affinity DataIC50:  12nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172227(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172227(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347396(CHEMBL1801568)
Affinity DataIC50:  13nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172217(6-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348074(CHEMBL1800522)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348029(CHEMBL1800426)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172212(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Kyowa Hakko Kogyo

LigandPNGBDBM50347411(CHEMBL1801556)
Affinity DataIC50:  15nMAssay Description:Inhibition of nicotinamide phosphoribosyltransferase-catalyzed conversion of nicotinamide to nicotinamide mononucleotideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177189(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant FVIIa/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172218(6-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177187(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant FVIIa/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172225(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172220(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50177200(6-[6-(3-carbamimidoyl-phenoxy)-4-diisopropylamino-...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant FVIIa/TF complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172232(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172224(2-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-(1-m...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against human coagulation factor VIIa/tissue factor cleavage of fluorogenic substrate SN17c at 37 degree C for 15 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
Myrexis

Curated by ChEMBL
LigandPNGBDBM50348066(CHEMBL1800514)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant C-terminal His6-tagged ICMT assessed as methylation of N-acetyl-S-geranylgeranylcysteine using SAM as methyl donor su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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