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Found 167 with Last Name = 'wren' and Initial = 'sp'
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Kingston University

Curated by ChEMBL
LigandPNGBDBM50606675(CHEMBL3219079)
Affinity DataKi:  0.900nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Kingston University

Curated by ChEMBL
LigandPNGBDBM50606676(CHEMBL3219087)
Affinity DataKi:  1nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Kingston University

Curated by ChEMBL
LigandPNGBDBM50606672(CHEMBL3219101)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Kingston University

Curated by ChEMBL
LigandPNGBDBM50606673(CHEMBL3219100)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Kingston University

Curated by ChEMBL
LigandPNGBDBM50606674(CHEMBL3219103)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Kingston University

Curated by ChEMBL
LigandPNGBDBM50606671(CHEMBL3219102)
Affinity DataKi:  3nMAssay Description:Inhibition of TMPRSS2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H-D cyclohexylalanine-Pro-Arg-AM as substrate by Dixon methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150708(4-Benzyl-N-[4-(2-diisopropylamino-ethoxy)-3-methox...)
Affinity DataKi:  79nMAssay Description:Binding affinity for Melanin-concentrating hormone 1 receptor expressed in CHO cells; Range is 40-79More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Kingston University

Curated by ChEMBL
LigandPNGBDBM50606668(CHEMBL5220314)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of recombinant human ACE2 using 7-Mca-YVADAPK (Dnp) as substrate by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Kingston University

Curated by ChEMBL
LigandPNGBDBM50606669(CHEMBL5220968)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant human ACE2 using 7-Mca-YVADAPK (Dnp) as substrate by fluorescence plate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150707(CHEMBL184291 | {[2,2-Diphenyl-5-(4-phenyl-piperidi...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150715(4''-Fluoro-biphenyl-4-carboxylic acid (6-dimethyla...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200783(ADS-103168 | CHEMBL424739 | N-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  9nMAssay Description:Inhibition of MCH-mediated calcium influx into MCH-R1 expressing cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200793(ADS-103214 | CHEMBL216430 | N-(1-methyl-2-(pyrroli...)
Affinity DataIC50:  9nMAssay Description:Inhibition of MCH-mediated calcium influx into MCH-R1 expressing cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Kingston University

Curated by ChEMBL
LigandPNGBDBM21489((2S)-2-{[(1S)-1-carboxy-2-{1-[(3,5-dichlorophenyl)...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of recombinant human ACE2 using 7-Mca-YVADAPK (Dnp) as substrate by fluorescence plate reader assayMore data for this Ligand-Target Pair
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150059(CHEMBL183215 | N-(4-Methyl-2-pyrrolidin-1-yl-quino...)
Affinity DataIC50:  10nMAssay Description:Inhibition of MCH-mediated calcium influx into MCH-R1 expressing cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150059(CHEMBL183215 | N-(4-Methyl-2-pyrrolidin-1-yl-quino...)
Affinity DataIC50:  10nMAssay Description:Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150709(2-(2,4-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150059(CHEMBL183215 | N-(4-Methyl-2-pyrrolidin-1-yl-quino...)
Affinity DataIC50:  15nMAssay Description:Displacement of 125I-[Phe13,Tyr19]-MCH from MCH-R1 expressing cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50241099(ADS-103274 | CHEMBL276393 | N-(2-((2-(dimethylamin...)
Affinity DataIC50:  25nMAssay Description:Displacement of 125I-[Phe13,Tyr19]-MCH from MCH-R1 expressing cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50149871((R)-2-((3-(biphenyl-4-yloxy)-3-(4-fluorophenyl)pro...)
Affinity DataIC50:  26nMAssay Description:Inhibition of uptake of [3H]-glycine into cells transfected with human GlyT-1b transporterChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50241099(ADS-103274 | CHEMBL276393 | N-(2-((2-(dimethylamin...)
Affinity DataIC50:  28nMAssay Description:Inhibition of MCH-mediated calcium influx into MCH-R1 expressing cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150710(2-(4-Chloro-phenoxy)-N-[2-(4-ethyl-piperazin-1-yl)...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200783(ADS-103168 | CHEMBL424739 | N-(2-(pyrrolidin-1-yl)...)
Affinity DataIC50:  35nMAssay Description:Displacement of 125I-[Phe13,Tyr19]-MCH from MCH-R1 expressing cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200793(ADS-103214 | CHEMBL216430 | N-(1-methyl-2-(pyrroli...)
Affinity DataIC50:  40nMAssay Description:Displacement of 125I-[Phe13,Tyr19]-MCH from MCH-R1 expressing cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200790(2-(4-methoxyphenoxy)-N-(4-methyl-2-(pyrrolidin-1-y...)
Affinity DataIC50:  41nMAssay Description:Inhibition of MCH-mediated calcium influx into MCH-R1 expressing cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140820(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  43nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150057(2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200788(2-(4-chlorophenoxy)-N-(4-methyl-2-(pyrrolidin-1-yl...)
Affinity DataIC50:  58nMAssay Description:Inhibition of MCH-mediated calcium influx into MCH-R1 expressing cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140825(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  61nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150063(CHEMBL364863 | N-[4-Methyl-2-(4-methyl-piperazin-1...)
Affinity DataIC50:  63nMAssay Description:Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200791(ADS-103294 | CHEMBL214678 | N-(2-(isopropylamino)-...)
Affinity DataIC50:  70nMAssay Description:Displacement of 125I-[Phe13,Tyr19]-MCH from MCH-R1 expressing cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150057(2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...)
Affinity DataIC50:  71nMAssay Description:Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140803(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  76nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200792(ADS-102891 | CHEMBL424728 | N-(4-methyl-2-(pyrroli...)
Affinity DataIC50:  100nMAssay Description:Inhibition of MCH-mediated calcium influx into MCH-R1 expressing cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200791(ADS-103294 | CHEMBL214678 | N-(2-(isopropylamino)-...)
Affinity DataIC50:  101nMAssay Description:Inhibition of MCH-mediated calcium influx into MCH-R1 expressing cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140804(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  105nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140798(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200794(CHEMBL216407 | N-(2-(piperazin-1-ylmethyl)quinolin...)
Affinity DataIC50:  122nMAssay Description:Displacement of 125I-[Phe13,Tyr19]-MCH from MCH-R1 expressing cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150064(CHEMBL182886 | N-(4-Methyl-2-morpholin-4-yl-quinol...)
Affinity DataIC50:  124nMAssay Description:Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140806(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  138nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50149875(CHEMBL361022 | {(R)-4-[5-Chloro-2-(4-methoxy-pheny...)
Affinity DataIC50:  150nMAssay Description:Inhibition of uptake of [3H]-glycine into cells transfected with human GlyT-1b transporterChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50149873(CHEMBL182162 | {(2R,5S)-4-[2-(4-Methoxy-phenylsulf...)
Affinity DataIC50:  160nMAssay Description:Inhibition of uptake of [3H]-glycine into cells transfected with human GlyT-1b transporterChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200785(ADS-103254 | CHEMBL217712 | N-(2-((2-(dimethylamin...)
Affinity DataIC50:  164nMAssay Description:Inhibition of MCH-mediated calcium influx into MCH-R1 expressing cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200792(ADS-102891 | CHEMBL424728 | N-(4-methyl-2-(pyrroli...)
Affinity DataIC50:  165nMAssay Description:Displacement of 125I-[Phe13,Tyr19]-MCH from MCH-R1 expressing cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50200784(CHEMBL217459 | N-(2-morpholinoquinolin-6-yl)-2-(4-...)
Affinity DataIC50:  172nMAssay Description:Displacement of 125I-[Phe13,Tyr19]-MCH from MCH-R1 expressing cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150072(2-(2,3-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Affinity DataIC50:  201nMAssay Description:Inhibitory activity against human 5-HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140814(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  218nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Xenova

Curated by ChEMBL
LigandPNGBDBM50140810(4-{4-[2-(3,4-Difluoro-phenyl)-ethyl]-piperazin-1-y...)
Affinity DataIC50:  229nMAssay Description:Inhibitory activity against human transporter MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150706(2-(2,4-Dichloro-phenoxy)-N-[2-(4-ethyl-piperazin-1...)
Affinity DataIC50:  230nMAssay Description:Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150716(3-(4-Methoxy-phenyl)-N-[4-methyl-2-(4-methyl-piper...)
Affinity DataIC50:  250nMAssay Description:Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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