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Found 760 with Last Name = 'wynn' and Initial = 'r'
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataKi:  1.10nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017412(CHEMBL345120 | Furan-2-carboxylic acid (1-phenethy...)
Affinity DataKi:  1.90nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  2.20nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017406(CHEMBL162700 | Furan-3-carboxylic acid benzo[1,2,5...)
Affinity DataKi:  2.60nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017416(CHEMBL347188 | Furan-2-carboxylic acid (4-methyl-p...)
Affinity DataKi:  4.10nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017404(CHEMBL161084 | Furan-2-carboxylic acid (1-phenethy...)
Affinity DataKi:  7.5nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017420(CHEMBL157922 | Furan-2-carboxylic acid (1-phenethy...)
Affinity DataKi:  7.70nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017403(CHEMBL161442 | Furan-2-carboxylic acid (1-phenethy...)
Affinity DataKi:  8.40nMAssay Description:The ability of the compound to displace [3H]-naloxone from the opioid receptor mu isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017405(2-Methoxy-N-(1-phenethyl-piperidin-4-yl)-N-pyridin...)
Affinity DataKi:  13nMAssay Description:The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017411(CHEMBL158857 | Furan-2-carboxylic acid (1-phenethy...)
Affinity DataKi:  14nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017410(2-Methoxy-N-(1-phenethyl-piperidin-4-yl)-N-pyrimid...)
Affinity DataKi:  16nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017409(CHEMBL161023 | Furan-2-carboxylic acid (6-chloro-p...)
Affinity DataKi:  19nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017414(CHEMBL161147 | Furan-3-carboxylic acid (2-chloro-p...)
Affinity DataKi:  21nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017413(CHEMBL161082 | Furan-2-carboxylic acid (2-chloro-p...)
Affinity DataKi:  22nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017402(CHEMBL158856 | Furan-3-carboxylic acid (1-phenethy...)
Affinity DataKi:  35nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017415(CHEMBL161487 | Furan-2-carboxylic acid morpholin-4...)
Affinity DataKi: >100nMAssay Description:The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; >= no displacementMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017408(CHEMBL351672 | Furan-3-carboxylic acid (1-phenethy...)
Affinity DataKi: >100nMAssay Description:The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; >= no displacementMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017407(CHEMBL161057 | Furan-3-carboxylic acid (6-chloro-p...)
Affinity DataKi: >100nMAssay Description:The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; >= absolutely no % changeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017401(CHEMBL422180 | Furan-3-carboxylic acid (1-phenethy...)
Affinity DataKi: >100nMAssay Description:The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; >= no displacementMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017400(CHEMBL352442 | Furan-3-carboxylic acid (2-chloro-p...)
Affinity DataKi: >100nMAssay Description:The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; >= no displacementMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017397(1-Phenethyl-piperidin-4-ylamine | CHEMBL423430)
Affinity DataKi: >100nMAssay Description:The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; >= no displacementMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017398(2-Methoxy-N-morpholin-4-yl-N-(1-phenethyl-piperidi...)
Affinity DataKi: >100nMAssay Description:The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; >= no displacementMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017419(2-Methoxy-N-(1-phenethyl-piperidin-4-yl)-N-piperid...)
Affinity DataKi: >100nMAssay Description:The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; >= no displacementMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017417(CHEMBL347810 | Furan-3-carboxylic acid (6-chloro-p...)
Affinity DataKi: >100nMAssay Description:The ability of the compound to displace [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane; >= no displacementMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017418(CHEMBL161512 | Furan-2-carboxylic acid (1-phenethy...)
Affinity DataKi: >100nMAssay Description:The ability of the compound to displace [3H]-naloxone from the opioid receptor mu isolated from rat brain membrane; >= no displacementMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM13465((2S)-N-[(1S)-1-carbamoyl-2-{4-[(5S)-1,1,3-trioxo-1...)
Affinity DataKi:  180nMAssay Description:Inhibition constant against protein-tyrosine phosphatase 1B by PNPP enzyme assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Boc Technical Center

Curated by ChEMBL
LigandPNGBDBM50017399(CHEMBL161280 | N-(6-Chloro-pyrimidin-4-yl)-2-metho...)
Affinity DataKi:  214nMAssay Description:Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300312(4-amino-1,2,5-oxadiazole-3-carboximidamide | CHEMB...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of N-terminal his-tagged human indoleamine 2,3-dioxygenase expressed in Escherichia coli assessed as N'-formylkynurenine formation by spec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataKi:  3.40E+4nMAssay Description:Competitive inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301217(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301217(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301220(3-(2-Chloro-6-fluoro-3,5-dimethoxyphenyl)-1-methyl...)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301217(3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301220(3-(2-Chloro-6-fluoro-3,5-dimethoxyphenyl)-1-methyl...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM13467((2R)-2-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...)
Affinity DataIC50:  0.400nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301220(3-(2-Chloro-6-fluoro-3,5-dimethoxyphenyl)-1-methyl...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595147(CHEMBL5205840)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301243(3'-(2,6-Difluoro-3,5-dimethoxyphenyl)-1'-methyl-4'...)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50566789(CHEMBL4862283)
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50566796(CHEMBL4871581)
Affinity DataIC50: <1nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595148(CHEMBL5202600)
Affinity DataIC50:  1nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301192(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301216(3-(2-Fluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,4,7-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595161(CHEMBL5172072)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301192(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301192(3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-methyl-1,3,...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50595158(CHEMBL5203601)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human11beta-HSD1 in human PBMC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50566796(CHEMBL4871581)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of VEGFR2 (unknown origin) incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301191(3-(2-Chloro-3,5-dimethoxyphenyl)-1-methyl-1,3,4,7-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human FGFR2 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM301216(3-(2-Fluoro-3,5-dimethoxyphenyl)-1-methyl-1,3,4,7-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human FGFR3 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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