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Found 246 with Last Name = 'yabuuchi' and Initial = 't'
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305129(6-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305140(7-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305119(7-(2-(dimethylamino)ethoxy)-2-(4-hydroxyphenyl)-9,...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305131(6-(3-(dimethylamino)propoxy)-2-(4-phenoxyphenyl)-9...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305139(6-(2-(4-methylpiperazin-1-yl)ethoxy)-2-(4-phenoxyp...)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305117(7-(2-morpholinoethoxy)-2-(4-phenoxyphenyl)-9,10-di...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305126(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305126(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305142(7-(2-hydroxyethoxy)-2-(4-phenoxyphenyl)-9,10-dihyd...)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305138(6-(2-morpholinoethoxy)-2-(4-phenoxyphenyl)-9,10-di...)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305121(7-(2-(dimethylamino)ethoxy)-2-(4-(phenylamino)phen...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305125(2-(4-(3-(2,6-dichlorophenyl)ureido)phenyl)-7-(2-(d...)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305135(2-(3-carbamoyl-2-(4-phenoxyphenyl)-9,10-dihydro-4H...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305122(2-(4-(2,6-dichlorobenzylamino)phenyl)-7-(2-(dimeth...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305141(7-(3-(dimethylamino)propoxy)-2-(4-phenoxyphenyl)-9...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305118(7-(2-(4-methylpiperazin-1-yl)ethoxy)-2-(4-phenoxyp...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305130(6-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305143(7-(2-amino-2-oxoethoxy)-2-(4-phenoxyphenyl)-9,10-d...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305132(6-(2-hydroxyethoxy)-2-(4-phenoxyphenyl)-9,10-dihyd...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305134(6-(2-amino-2-oxoethoxy)-2-(4-phenoxyphenyl)-9,10-d...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166423(US9073821, 550)
Affinity DataIC50:  1.60nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305126(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of CskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305123(CHEMBL595625 | benzyl 4-(3-carbamoyl-7-(2-(dimethy...)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166411(US9073821, 376)
Affinity DataIC50:  2nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305124(7-(2-(dimethylamino)ethoxy)-2-(4-(3-phenylureido)p...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166426(US9073821, 557)
Affinity DataIC50:  2.30nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305128(7-methoxy-2-(4-phenoxyphenyl)-9,10-dihydro-4H-benz...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402166(CHEMBL2207988)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166418(US9073821, 434)
Affinity DataIC50:  2.80nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305145(2-(4-phenoxyphenyl)-7-(pyridin-3-ylmethoxy)-9,10-d...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166415(US9073821, 405)
Affinity DataIC50:  2.90nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402251(CHEMBL2204791)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PI3Kgamma using phosphatidylinositol as substrate and [33gammaP]ATP after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402256(CHEMBL2204786)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PI3Kgamma using phosphatidylinositol as substrate and [33gammaP]ATP after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402251(CHEMBL2204791)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PI3Kgamma using PtdIns/PtdSer as substrate after 2 hrs by scintillation counting analysis in presence of gamma[33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166412(US9073821, 396)
Affinity DataIC50:  3.10nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166409(US9073821, 211)
Affinity DataIC50:  3.10nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166388(US9073821, 3)
Affinity DataIC50:  3.30nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166432(US9073821, 585)
Affinity DataIC50:  3.40nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166390(US9073821, 5)
Affinity DataIC50:  3.70nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166430(US9073821, 563)
Affinity DataIC50:  3.90nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305136(6-(2-oxopropoxy)-2-(4-phenoxyphenyl)-9,10-dihydro-...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305120(2-(4-aminophenyl)-7-(2-(dimethylamino)ethoxy)-9,10...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of GST-tagged human LCK by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166408(US9073821, 168)
Affinity DataIC50:  4.20nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166419(US9073821, 477)
Affinity DataIC50:  4.30nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50402175(CHEMBL2208016)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human ALK5 using GST-tagged Smad3 as substrate assessed as substrate phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166406(US9073821, 237)
Affinity DataIC50:  4.5nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50305146(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of CskMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166396(US9073821, 52)
Affinity DataIC50:  4.60nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166394(US9073821, 40)
Affinity DataIC50:  4.70nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa)
Taisho Pharmaceutical

US Patent
LigandPNGBDBM166422(US9073821, 528)
Affinity DataIC50:  4.80nMpH: 8.0 T: 2°CAssay Description:To assay the activity of Pseudomonas aeruginosa LpxC enzyme, LpxC was reacted with its substrate UDP-3-O-(R-3-hydroxydecanoyl)-N-acetylglucosamine an...More data for this Ligand-Target Pair
In DepthDetails US Patent
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