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Found 429 with Last Name = 'yadav' and Initial = 'p'
TargetHistamine H3 receptor(Homo sapiens (Human))
Academy Of Scientific And Innovative Research (Acsir)

Curated by ChEMBL
LigandPNGBDBM50524365(CHEMBL4579211)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from recombinant human H3 receptor expressed in HEK293T cells measured after 90 mins by liquid scintillat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Academy Of Scientific And Innovative Research (Acsir)

Curated by ChEMBL
LigandPNGBDBM50524374(CHEMBL4453810)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from recombinant human H3 receptor expressed in HEK293T cells measured after 90 mins by liquid scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50182133(3-(4-methoxybenzofuran-5-yl)-5-(4-methoxyphenyl)-4...)
Affinity DataKi:  2.75E+4nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50182134(3-(4,7-dimethoxybenzofuran-5-yl)-5-phenyl-4,5-dihy...)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50182131(3-(4,7-dimethoxybenzofuran-5-yl)-5-(4-methoxypheny...)
Affinity DataKi:  3.20E+4nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50182135(3-(4-methoxybenzofuran-5-yl)-5-phenyl-4,5-dihydroi...)
Affinity DataKi:  4.50E+4nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50182132(CHEMBL205730 | methyl 3-(4-methoxybenzofuran-5-yl)...)
Affinity DataKi:  7.25E+4nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Alkem Laboratories

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataIC50:  0.692nMAssay Description:Agonist activity at recombinant human KOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP level preincubated for 15 to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Alkem Laboratories

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataIC50:  0.692nMAssay Description:Antagonist activity at recombinant human MOR expressed in HEK293T cells assessed as reduction in DAMGO-induced inhibition of forskolin-stimulated cAM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50028854(CHEMBL3342693)
Affinity DataIC50:  0.940nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50:  1nMAssay Description:Inhibition of human cathepsin CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50381287(CHEMBL2019020)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]-cAMP from human recombinant PDE7AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50028853(CHEMBL3342695)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant mPGES-1 using PGH2 as substrate incubated for 25 mins prior to substrate addition measured after 1 min by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007086(CHEMBL3237558)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50028860(CHEMBL3342699)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkem Laboratories

Curated by ChEMBL
LigandPNGBDBM50088381(ADL 8-2698 | Alvimopan | Entereg)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at recombinant human MOR expressed in HEK293T cells assessed as reduction in DAMGO-induced inhibition of forskolin-stimulated cAM...More data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50028784(CHEMBL3342692)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007105(CHEMBL3237573)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007039(CHEMBL3237556)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007186(CHEMBL3237580)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Alkem Laboratories

Curated by ChEMBL
LigandPNGBDBM50088381(ADL 8-2698 | Alvimopan | Entereg)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at recombinant human MOR expressed in HEK293T cells assessed as reduction in DAMGO-induced inhibition of forskolin-stimulated cAM...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50381291(CHEMBL2019104)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-cAMP from human recombinant PDE7AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007088(CHEMBL3237559)
Affinity DataIC50:  4nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099407(CHEMBL3342851)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007094(CHEMBL3237565)
Affinity DataIC50:  4nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50568317(CHEMBL4865824)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human cathepsin CMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007068(CHEMBL3237557)
Affinity DataIC50:  5nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007090(CHEMBL3237561)
Affinity DataIC50:  5nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007092(CHEMBL3237563)
Affinity DataIC50:  5nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099410(CHEMBL3342849)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50011502(CHEMBL3261926)
Affinity DataIC50:  5nMAssay Description:Inhibition of cellular cathepsin C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50028861(CHEMBL3342700)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099410(CHEMBL3342849)
Affinity DataIC50:  5nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as inhibition of IL-1beta-induced PGE2 production incubated for 30 mins prior to IL-1beta challeng...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007106(CHEMBL3237574)
Affinity DataIC50:  5nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099411(CHEMBL3342848)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007104(CHEMBL3237572 | US10112928, Compound I-17)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50568319(CHEMBL4869673)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of human cathepsin CMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50381296(CHEMBL2019109)
Affinity DataIC50:  7nMAssay Description:Displacement of [3H]-cAMP from human recombinant PDE7AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50028871(CHEMBL3342712)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
University Of Delhi

Curated by ChEMBL
LigandPNGBDBM25351(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Affinity DataIC50:  7nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity preincubated for 30 mins followed by addition of FITC-labelled dsDNA for 1 hr by microplate re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50381299(CHEMBL2019112)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]-cAMP from human recombinant PDE7BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50381293(CHEMBL2019106)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]-cAMP from human recombinant PDE7AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50381290(CHEMBL2019103)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]-cAMP from human recombinant PDE7AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50568314(CHEMBL4856217)
Affinity DataIC50:  9.30nMAssay Description:Inhibition of human cathepsin CMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007038(CHEMBL3233058)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007093(CHEMBL3237564)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007115(CHEMBL3237575)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50007122(CHEMBL3237576)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SYK (360 to 635) using biotin-EPEGDYEEVLE as substrate preincubated for 10 mins followed by substrate/ATP/[33Pgamma]ATP addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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