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Found 3677 with Last Name = 'ye' and Initial = 'x'
TargetAdenosine receptor A2a(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50595097(CHEMBL5170337)
Affinity DataKi:  0.220nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50507371(BMS-823778)
Affinity DataKi:  0.900nMAssay Description:Inhibition of recombinant human 11beta-HSD1 expressed in HEK293 cell microsomes using [3H]cortisone as substrate after 4 hrs by homogeneous immuno-ra...More data for this Ligand-Target Pair
TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataKi: <1nMAssay Description:Displacement of 5-FAM labelled tracer from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM200723(US9233086, 10L)
Affinity DataKi: <1nMAssay Description:Displacement of 5-FAM labelled tracer from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM200722(US9233086, 10K)
Affinity DataKi: <1nMAssay Description:Displacement of 5-FAM labelled tracer from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50092173(CHEMBL325710 | N*6*,N*6*-Dipropyl-6,7-dihydro-5H-1...)
Affinity DataKi:  1.40nMAssay Description:Agonist activity at dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50123627((S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)
Affinity DataKi:  2nMAssay Description:Agonist activity at dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50048466(2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,...)
Affinity DataKi:  2.30nMAssay Description:Antagonist activity at adenosine A2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM50131550((3S)-3-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212359(CHEMBL558182 | threo-1-aza-4beta-hydroxy-5-(3,4-di...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50123627((S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)
Affinity DataKi:  3nMAssay Description:Agonist activity at dopamine D1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212365(CHEMBL556365 | threo-1-aza-5-(3,4-dichlorophenyl)[...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212361((1R,2R,9aR)-1-(3,4-dichlorophenyl)-2-ethyl-octahyd...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239606(CHEMBL4080667)
Affinity DataKi:  3.80nMAssay Description:Inhibition of 11beta-HSD1 in human microsomes using [3H]cortisone as substrate preincubated for 10 mins followed by substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212387(CHEMBL537653 | threo-3,4-dichlororitalinol hydroch...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50152240(CHEMBL184309 | N*5*-{2-[4-(2,4-Difluoro-phenyl)-pi...)
Affinity DataKi:  4nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212383((1R,2S,9aR)-1-(3,4-dichlorophenyl)-2-ethyl-octahyd...)
Affinity DataKi:  4.10nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50142840((R)-2-[(R)-(3,4-Dichloro-phenyl)-methoxycarbonyl-m...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212373((1R,2S,9aR)-2-ethyl-1-phenyl-octahydro-1H-quinoliz...)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50499055(CHEMBL3735985)
Affinity DataKi:  6.30nMAssay Description:Antagonist activity at rat adenosine A1 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50202086(CHEMBL219142 | N-[(E)-5-hydroxy-2-adamantyl]-2-{4-...)
Affinity DataKi:  8nMAssay Description:Inhibition of human 11beta-HSD-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50102258((S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-...)
Affinity DataKi:  8nMAssay Description:Binding affinity PSMA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50499055(CHEMBL3735985)
Affinity DataKi:  9.5nMAssay Description:Antagonist activity at rat adenosine A2A receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50152215(7N-[1-(2-chloro-4-pyridylmethyl)-(2R)-tetrahydro-1...)
Affinity DataKi:  10nMAssay Description:Antagonist activity at rat adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50011294(A2A | Ro-4494351 | Ro-4494351-002 | Ro-4494351000 ...)
Affinity DataKi:  11nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212381(CHEMBL537874 | threo-1-aza-4beta-methoxy-5-phenyl[...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212385(CHEMBL558394 | threo-1-aza-4-oxo-5-(3,4-dichloroph...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50501643(CHEMBL4065191)
Affinity DataKi:  16nMAssay Description:Inhibition of recombinant human N-terminal His-tagged ST6Gal-1 (44 to 406 residues) using CMP-Neu5Ac as substrate after 20 mins by UV/RP-HPLC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50501643(CHEMBL4065191)
Affinity DataKi:  16nMAssay Description:Inhibition of recombinant human N-terminal His-tagged ST6Gal-1 (44 to 406 residues) using CMP-Neu5Ac as substrate after 20 mins by UV/RP-HPLC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50501640(CHEMBL4102509)
Affinity DataKi:  19nMAssay Description:Inhibition of recombinant human N-terminal His-tagged ST6Gal-1 (44 to 406 residues) using CMP-Neu5Ac as substrate after 20 mins by UV/RP-HPLC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50127702(CHEMBL3629697)
Affinity DataKi:  19nMAssay Description:Competitive inhibition of human recombinant ST6Gal-1 using CMP-Neu5Ac and p-nitrophenyl LacNAc as donar and acceptor by Lineweaver-Burk double recipr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50501638(CHEMBL4091389)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant human N-terminal His-tagged ST6Gal-1 (44 to 406 residues) using CMP-Neu5Ac as substrate after 20 mins by UV/RP-HPLC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50501638(CHEMBL4091389)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant human N-terminal His-tagged ST6Gal-1 (44 to 406 residues) using CMP-Neu5Ac as substrate after 20 mins by UV/RP-HPLC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM50131550((3S)-3-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...)
Affinity DataKi:  24nMAssay Description:Inhibition of TCPTP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50092173(CHEMBL325710 | N*6*,N*6*-Dipropyl-6,7-dihydro-5H-1...)
Affinity DataKi:  27nMAssay Description:Agonist activity at dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50092312(Birabresib | MK-8628 | OTX-015)
Affinity DataKi:  27nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using FAM-labeled JQ-1 as fluorescent substrate assessed as inhibition constant incubated for 30 mins by comp...More data for this Ligand-Target Pair
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50127703(CHEMBL3629696)
Affinity DataKi:  28nMAssay Description:Inhibition of recombinant human N-terminal His-tagged ST6Gal-1 (44 to 406 residues) using CMP-Neu5Ac as substrate after 20 mins by UV/RP-HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212371((1R,2R,9aR)-2-ethyl-1-phenyl-octahydro-1H-quinoliz...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50127703(CHEMBL3629696)
Affinity DataKi:  28nMAssay Description:Competitive inhibition of human recombinant ST6Gal-1 using CMP-Neu5Ac and p-nitrophenyl LacNAc as donar and acceptor by Lineweaver-Burk double recipr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50127703(CHEMBL3629696)
Affinity DataKi:  28nMAssay Description:Inhibition of recombinant human N-terminal His-tagged ST6Gal-1 (44 to 406 residues) using CMP-Neu5Ac as substrate after 20 mins by UV/RP-HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212365(CHEMBL556365 | threo-1-aza-5-(3,4-dichlorophenyl)[...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat cortical tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50127703(CHEMBL3629696)
Affinity DataKi:  28nMAssay Description:Competitive inhibition of human recombinant ST6Gal-1 using CMP-Neu5Ac and p-nitrophenyl LacNAc as donar and acceptor by Lineweaver-Burk double recipr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212359(CHEMBL558182 | threo-1-aza-4beta-hydroxy-5-(3,4-di...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat cortical tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50501642(CHEMBL3629698)
Affinity DataKi:  29nMAssay Description:Inhibition of recombinant human N-terminal His-tagged ST6Gal-1 (44 to 406 residues) using CMP-Neu5Ac as substrate after 20 mins by UV/RP-HPLC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50501642(CHEMBL3629698)
Affinity DataKi:  29nMAssay Description:Inhibition of recombinant human N-terminal His-tagged ST6Gal-1 (44 to 406 residues) using CMP-Neu5Ac as substrate after 20 mins by UV/RP-HPLC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212363(CHEMBL559186 | erythro-1-aza-5-(3,4-dichlorophenyl...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50212382(CHEMBL537652 | threo-1-aza-4alpha-hydroxy-5-(3,4-d...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50594647(CHEMBL5182020)
Affinity DataKi:  54nMAssay Description:Antagonist activity at human adenosine A2A receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50501637(CHEMBL4063545)
Affinity DataKi:  60nMAssay Description:Inhibition of recombinant human N-terminal His-tagged ST6Gal-1 (44 to 406 residues) using CMP-Neu5Ac as substrate after 20 mins by UV/RP-HPLC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-galactoside alpha-2,6-sialyltransferase 1(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM50501637(CHEMBL4063545)
Affinity DataKi:  60nMAssay Description:Inhibition of recombinant human N-terminal His-tagged ST6Gal-1 (44 to 406 residues) using CMP-Neu5Ac as substrate after 20 mins by UV/RP-HPLC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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