Compile Data Set for Download or QSAR
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Found 227 with Last Name = 'yingling' and Initial = 'jm'
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132988(4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)
Affinity DataIC50:  2.90nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132988(4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...)
Affinity DataIC50:  2.90nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132986(4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...)
Affinity DataIC50:  6.80nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)
Affinity DataIC50:  7.10nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184486(1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)
Affinity DataIC50:  8nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184488(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Affinity DataIC50:  15nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184483(1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21506(Dihydropyrrolopyrazole, 15a | dimethyl[2-({4-[2-(p...)
Affinity DataIC50:  24nM EC50:  29nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132981(4-[5-Methyl-3-(6-methyl-pyridin-2-yl)-1H-pyrazol-4...)
Affinity DataIC50:  24nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132993(4-(3-Phenyl-1H-pyrazol-4-yl)-quinoline | 4-(3-phen...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184483(1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...)
Affinity DataIC50:  29nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132988(4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132992(4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)phenol...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132992(4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)phenol...)
Affinity DataIC50:  32nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21505(7-(2-chloroethoxy)-4-[2-(pyridin-2-yl)-4H,5H,6H-py...)
Affinity DataIC50:  33nM EC50:  66nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)
Affinity DataIC50:  34nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataIC50:  40nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184489(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...)
Affinity DataIC50:  41nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132976(2-[4-(4-Fluoro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)
Affinity DataIC50:  41nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132987(2-[4-(4-Methoxy-phenyl)-1-methyl-1H-pyrazol-3-yl]-...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132992(4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)phenol...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataIC50:  47nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50148668(4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo...)
Affinity DataIC50:  47nMAssay Description:Inhibitory activity against TGF-beta type I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21510(Dihydropyrrolopyrazole, 16a | dimethyl[5-({4-[2-(p...)
Affinity DataIC50:  47nM EC50:  24nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184488(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Affinity DataIC50:  47nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132987(2-[4-(4-Methoxy-phenyl)-1-methyl-1H-pyrazol-3-yl]-...)
Affinity DataIC50:  47nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50148666(7-Chloro-4-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-...)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity against TGF-beta type I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21511(1-(4-methylpiperazin-1-yl)-2-({4-[2-(pyridin-2-yl)...)
Affinity DataIC50:  49nM EC50:  260nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184494(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Affinity DataIC50:  51nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human Transforming growth factor (TGF) beta-1 receptor (T204D mutation) autophosphorylation in Sf9 cellsMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184496(CHEMBL441176 | dimethyl-(3-{6-[2-(6-methyl-pyridin...)
Affinity DataIC50:  53nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50148655(7-Chloro-4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)
Affinity DataIC50:  54nMAssay Description:Inhibitory activity against TGF-beta type I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132994(2-[4-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)
Affinity DataIC50:  57nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataIC50:  59nM EC50:  40nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataIC50:  59nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50148657(7-Ethoxy-4-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-...)
Affinity DataIC50:  59nMAssay Description:Inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132987(2-[4-(4-Methoxy-phenyl)-1-methyl-1H-pyrazol-3-yl]-...)
Affinity DataIC50:  61nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21509(4-[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]...)
Affinity DataIC50:  69nM EC50:  180nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184487(4-(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-p...)
Affinity DataIC50:  69nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132976(2-[4-(4-Fluoro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50148656(4-(2-(6-ethylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[...)
Affinity DataIC50:  71nMAssay Description:Inhibitory activity against TGF-beta type I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21513(7-[3-(1-methylpyrrolidin-2-yl)propoxy]-4-[2-(pyrid...)
Affinity DataIC50:  72nM EC50:  17nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184497(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)
Affinity DataIC50:  74nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21504(7-[3-(4-methylpiperazin-1-yl)propoxy]-4-[2-(pyridi...)
Affinity DataIC50:  74nM EC50:  44nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184486(1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)
Affinity DataIC50:  75nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132980(4-(3-(5-fluoropyridin-2-yl)-1H-pyrazol-4-yl)quinol...)
Affinity DataIC50:  76nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)
Affinity DataIC50:  78nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50184489(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...)
Affinity DataIC50:  78nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50148661(4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo...)
Affinity DataIC50:  78nMAssay Description:Inhibitory activity against TGF-beta type I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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