Affinity DataKi: 0.140nMAssay Description:Inhibition of human recombinant melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataKi: 0.170nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataKi: 0.220nMAssay Description:Displacement of [3H]4-DAMP from human recombinant Muscarinic acetylcholine receptor M3 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:Displacement of [3H]methyl-spiperone from human recombinant D2S receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataKi: 0.280nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataKi: 0.450nMAssay Description:Displacement of [3H]U 69593 from rat recombinant kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Displacement of (S)-N-(2-(1H-pyrrol-1-yl)phenyl)-1-(2-((3H)-1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX2 rec...More data for this Ligand-Target Pair
Affinity DataKi: 0.710nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H]nisoxetine from human recombinant norepinephrine transporter expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataKi: 6.20nMAssay Description:Displacement of [3H]BTCP from human recombinant dopamine transporter expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 9.80nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 2(Mus musculus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 betaMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataKi: 24nMAssay Description:Displacement of [3H]pirenzepine from human recombinant Muscarinic acetylcholine receptor M1 expressed in CHO cells after 60 mins by scintillation cou...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Displacement of (S)-N-(2-(1H-pyrrol-1-yl)phenyl)-1-(2-((3H)-1-methyl-1H-benzo[d]imidazol-2-ylthio)acetyl)pyrrolidine-2-carboxamide from human OX2 rec...More data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 2(Mus musculus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 45nMAssay Description:Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 betaMore data for this Ligand-Target Pair
Affinity DataKi: 46nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 51nMAssay Description:Binding affinity to rat OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 51nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 54nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataKi: 61nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT6 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 2(Mus musculus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 75nMAssay Description:Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 betaMore data for this Ligand-Target Pair
Affinity DataKi: 77nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 2(Mus musculus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 86nMAssay Description:Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 betaMore data for this Ligand-Target Pair
Affinity DataKi: 106nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 110nMAssay Description:Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
The University Of Newcastle
Curated by ChEMBL
The University Of Newcastle
Curated by ChEMBL
Affinity DataKi: 130nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT5a receptor in HEK293 cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 137nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataKi: 141nMAssay Description:Binding affinity to human OX2 receptorMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Rattus norvegicus (rat))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 160nMAssay Description:Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair