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Found 112 with Last Name = 'zemribo' and Initial = 'r'
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391055(CHEMBL2088399)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391031(CHEMBL2088393)
Affinity DataIC50:  9.80nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391029(CHEMBL2088391)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50231755(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Affinity DataIC50:  23nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391027(CHEMBL2088401)
Affinity DataIC50:  27nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391025(CHEMBL2088398)
Affinity DataIC50:  27nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443088(CHEMBL3087216)
Affinity DataIC50:  27nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438277(CHEMBL2408412)
Affinity DataIC50:  28nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443089(CHEMBL3086715)
Affinity DataIC50:  28nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443089(CHEMBL3086715)
Affinity DataIC50:  28.4nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391032(CHEMBL2088394)
Affinity DataIC50:  33nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438295(CHEMBL2408568)
Affinity DataIC50:  34nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443090(CHEMBL3086712)
Affinity DataIC50:  37nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391040(CHEMBL2088406)
Affinity DataIC50:  41nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438289(CHEMBL2408574)
Affinity DataIC50:  43nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443091(CHEMBL3087511)
Affinity DataIC50:  47nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391052(CHEMBL2088419)
Affinity DataIC50:  47nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443092(CHEMBL3085792)
Affinity DataIC50:  48nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443093(CHEMBL3087217)
Affinity DataIC50:  51nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391037(CHEMBL2088403)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391053(CHEMBL2088420)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443087(CHEMBL3087214)
Affinity DataIC50:  61nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443086(CHEMBL3087508)
Affinity DataIC50:  65nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438278(CHEMBL2408411)
Affinity DataIC50:  68nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391026(CHEMBL2088400)
Affinity DataIC50:  68nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443085(AFQ056 | Mavoglurant)
Affinity DataIC50:  72nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443084(CHEMBL3087220)
Affinity DataIC50:  72nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443083(CHEMBL3087219)
Affinity DataIC50:  76nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438294(CHEMBL2408569)
Affinity DataIC50:  83nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443082(CHEMBL3087513)
Affinity DataIC50:  85nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438298(CHEMBL2408565)
Affinity DataIC50:  85nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391039(CHEMBL2088405)
Affinity DataIC50:  86nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391051(CHEMBL2088418)
Affinity DataIC50:  86nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443081(CHEMBL3087212)
Affinity DataIC50:  86nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443080(CHEMBL3087514)
Affinity DataIC50:  103nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443080(CHEMBL3087514)
Affinity DataIC50:  103nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438288(CHEMBL2408575)
Affinity DataIC50:  111nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438305(CHEMBL2408585)
Affinity DataIC50:  120nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438291(CHEMBL2408572)
Affinity DataIC50:  125nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443079(CHEMBL3087225)
Affinity DataIC50:  132nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443078(CHEMBL3087509)
Affinity DataIC50:  137nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391041(CHEMBL2088407)
Affinity DataIC50:  157nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438293(CHEMBL2408570)
Affinity DataIC50:  157nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443077(CHEMBL3087505)
Affinity DataIC50:  168nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438298(CHEMBL2408565)
Affinity DataIC50:  170nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50438298(CHEMBL2408565)
Affinity DataIC50:  170nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443076(CHEMBL3087507)
Affinity DataIC50:  170nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391028(CHEMBL2088390)
Affinity DataIC50:  175nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443075(CHEMBL3086717)
Affinity DataIC50:  180nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merz Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50443074(CHEMBL3087218)
Affinity DataIC50:  187nMAssay Description:Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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