Affinity DataKi: 0.290nMAssay Description:Binding affinity to EED (unknown origin) by TR-FRET based binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Displacement of OG(488) labeled probe from GST-tagged EED (unknown origin) incubated for 1 hr by lanthaScreen TR-FRET methodMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Inhibition of human FLAG-tagged EZH2 using H3K27me as substrate in presence of [3H]-SAM incubated for 30 mins by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor expressed in CHO cell membranes incubated for 1 hr by micro beta2 scintillation c...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
"G. D'Annunzio" University Of Chieti-Pescara
Curated by ChEMBL
"G. D'Annunzio" University Of Chieti-Pescara
Curated by ChEMBL
Affinity DataKi: 7.30nMAssay Description:Competitive inhibition of recombinant human MAO-B using kynuramine as substrate pre-incubated for 15 mins followed by 2 fold compound dilution for 24...More data for this Ligand-Target Pair
Affinity DataKi: 7.30nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor expressed in CHO cell membranes incubated for 1 hr by micro beta2 scintillation c...More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Binding affinity to EED (unknown origin) by TR-FRET based binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Binding affinity to EED (unknown origin) by TR-FRET based binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Displacement of [3H]diprenorphine human delta opioid receptor expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Displacement of [3H]-diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by micro beta2 scintillation c...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 24nMAssay Description:Competitive inhibition of wild type EZH2 in human PRC2 complex using S-adenosylmethionine as substrate by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Displacement of [3H]diprenorphine human MOR expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 51nMAssay Description:Displacement of [3H]-diprenorphine from human mu opioid receptor expressed in CHO cell membranes incubated for 1 hr by micro beta2 scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 54nMAssay Description:Displacement of [3H]-diprenorphine from human mu opioid receptor expressed in CHO cell membranes incubated for 1 hr by micro beta2 scintillation coun...More data for this Ligand-Target Pair
Affinity DataKi: 70nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor expressed in CHO cell membranes incubated for 1 hr by micro beta2 scintillation c...More data for this Ligand-Target Pair
Affinity DataKi: 76nMAssay Description:Displacement of [3H]-diprenorphine from human mu opioid receptor expressed in CHO cell membranes incubated for 1 hr by micro beta2 scintillation coun...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 80nMAssay Description:Inhibition of wild type EZH2 in human PRC2 complex using S-adenosylmethionine and biotinylated histone peptides as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 91nMAssay Description:Displacement of [3H]diprenorphine human MOR expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 98nMAssay Description:Displacement of [3H]diprenorphine human delta opioid receptor expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Displacement of [3H]diprenorphine human delta opioid receptor expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Displacement of [3H]diprenorphine human delta opioid receptor expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Displacement of [3H]diprenorphine human kappa opioid receptor expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting methodMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 180nMAssay Description:Inhibition of wild type EZH2 in human PRC2 complex using S-adenosylmethionine and biotinylated histone peptides as substrateMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 310nMAssay Description:Inhibition of wild type EZH2 in human PRC2 complex using S-adenosylmethionine and biotinylated histone peptides as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:Binding affinity to EED (unknown origin) by TR-FRET based binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 495nMAssay Description:Displacement of [3H]-diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by micro beta2 scintillation c...More data for this Ligand-Target Pair
Affinity DataKi: 510nMAssay Description:Displacement of [3H]diprenorphine human MOR expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 600nMAssay Description:Binding affinity to EED (unknown origin) by TR-FRET based binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 686nMAssay Description:Displacement of [3H]-diprenorphine from human kappa opioid receptor expressed in CHO cell membranes incubated for 1 hr by micro beta2 scintillation c...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 700nMAssay Description:Inhibition of human FLAG-tev-fused EZH2 expressed in baculovirus infected Sf9 insect cells using H3K27 peptide as substrate in presence of [3H]-SAM b...More data for this Ligand-Target Pair
Affinity DataKi: 790nMAssay Description:Displacement of [3H]diprenorphine human MOR expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.83E+3nMAssay Description:Displacement of OG(488) labeled probe from GST-tagged EED (unknown origin) incubated for 1 hr by lanthaScreen TR-FRET methodMore data for this Ligand-Target Pair
Affinity DataKi: >3.33E+3nMAssay Description:Displacement of [3H]diprenorphine human kappa opioid receptor expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: >3.33E+3nMAssay Description:Displacement of [3H]diprenorphine human kappa opioid receptor expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: >3.33E+3nMAssay Description:Displacement of [3H]diprenorphine human kappa opioid receptor expressed in CHO cell membranes after 1 hr by micro beta2 scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0251nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0257nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0288nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0724nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.129nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.339nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.360nMAssay Description:Antagonist activity at human delta opioid receptor expressed in CHO cell membranes assessed as reduction in SNC80-induced [35S]GTPgammaS binding incu...More data for this Ligand-Target Pair
Affinity DataIC50: 0.372nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.407nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.417nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
Affinity DataIC50: 0.487nMAssay Description:Inhibition of human alpha-v-beta-3 integrin receptor by ELISAMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild type EZH2 (unknown origin) using histone H3 peptide (17 to 38 residues) by radiometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: <0.510nMAssay Description:Antagonist activity at human delta opioid receptor expressed in CHO cells assessed as reduction in SNC80-induced inhibition of forskolin stimulated c...More data for this Ligand-Target Pair
Affinity DataIC50: 0.646nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair