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Found 81 with Last Name = 'zhang' and Initial = 'aq'
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343301(2-((4-(4-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343305(2-((4-(4-Chloro-2-fluorophenyl)piperidin-1-yl)meth...)
Affinity DataKi:  91nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataKi:  93nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343317(1-methyl-2-(((1R,5S)-3-(4-(trifluoromethyl)phenyl)...)
Affinity DataKi:  355nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343308(1-Methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataKi:  404nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343295(2-((4-(2-Methoxy-phenyl)piperidin-1-yl)methyl)-1-m...)
Affinity DataKi:  426nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343306(1-methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataKi:  561nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343316(CHEMBL1774224 | cis-1-methyl-2-(((2R,4R)-2-methyl-...)
Affinity DataKi:  589nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343309(1-Methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataKi:  671nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343314(2-((4-(2-Fluoro-4-(trifluoromethoxy)phenyl)piperid...)
Affinity DataKi:  1.18E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343321(CHEMBL1774229 | cis-2-(((3R,4R)-4-(4-chloro-2-fluo...)
Affinity DataKi:  1.62E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343313(2-((4-(2-Fluoro-4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataKi:  1.78E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343312(2-((4-(2-Methoxy-4-(trifluoromethyl)phenyl)piperid...)
Affinity DataKi:  2.43E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343320(CHEMBL1774228 | cis-1-methyl-2-(((3S,4S)-3-methyl-...)
Affinity DataKi: >2.80E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343319(CHEMBL1774227 | cis-1-methyl-2-(((3R,4R)-3-methyl-...)
Affinity DataKi: >2.80E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343318((S)-2-((3,3-dimethyl-4-(4-(trifluoromethyl)phenyl)...)
Affinity DataKi: >2.80E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343319(CHEMBL1774227 | cis-1-methyl-2-(((3R,4R)-3-methyl-...)
Affinity DataKi: >2.80E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343327(CHEMBL1774235 | cis-2-(((3R,4R)-4-(2-fluoro-4-(tri...)
Affinity DataKi: >4.68E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343325(CHEMBL1774233 | cis-2-(((3R,4R)-4-(2-fluoro-4-(tri...)
Affinity DataKi: >5.26E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343323(CHEMBL1774231 | cis-2-(((3R,4R)-4-(2-methoxy-4-(tr...)
Affinity DataKi: >5.26E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263432(2-(((1R,5S)-6-((6-chloropyridin-3-yloxy)methyl)-3-...)
Affinity DataEC50:  511nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263433(1-methyl-2-(((1R,5S)-6-((5-(trifluoromethyl)pyridi...)
Affinity DataEC50:  30nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263434(1-methyl-2-(((1R,5S)-6-((4-(trifluoromethyl)phenox...)
Affinity DataEC50:  20nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50274140(1-methyl-2-(((1R,5S)-6-((4-(trifluoromethyl)phenox...)
Affinity DataEC50:  251nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50274141(3-methyl-2-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyc...)
Affinity DataEC50:  2.12E+3nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50274142(3-methyl-2-(((1R,5S)-6-((4-(trifluoromethyl)phenox...)
Affinity DataEC50:  419nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50274143(2-(((1R,5S)-6-((3-chlorophenoxy)methyl)-3-aza-bicy...)
Affinity DataEC50:  64nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50274144(2-(((1R,5S)-6-((3-chlorophenoxy)methyl)-3-aza-bicy...)
Affinity DataEC50:  86nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263426(1-methyl-2-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyc...)
Affinity DataEC50:  24nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263427(2-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyclo[3.1.0]...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263428(2-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyclo[3.1.0]...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263429(3-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyclo[3.1.0]...)
Affinity DataEC50:  9.75E+3nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263430(1-cyclopropyl-2-(((1R,5S)-6-(phenoxymethyl)-3-aza-...)
Affinity DataEC50:  3.02E+3nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263353(1-(((1R,5S)-6-(phenoxymethyl)-3-aza-bicyclo[3.1.0]...)
Affinity DataEC50:  967nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263354(2-[(1R,5S)-6-(Biphenyl-3-yloxymethyl)-3-aza-bicycl...)
Affinity DataEC50:  113nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263355(2-(((1R,5S)-6-((2,5-difluorophenoxy)methyl)-3-aza-...)
Affinity DataEC50:  7nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263389(2-(((1R,5S)-6-((4-isopropylphenoxy)methyl)-3-aza-b...)
Affinity DataEC50:  26nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263390(2-(((1R,5S)-6-((4-chlorophenoxy)methyl)-3-aza-bicy...)
Affinity DataEC50:  26nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263391(2-(((1R,5S)-6-((4-chloro-2-fluorophenoxy)methyl)-3...)
Affinity DataEC50:  8nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263392(1-methyl-2-(((1R,5S)-6-((4-(trifluoromethyl)phenox...)
Affinity DataEC50:  85nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50263431(2-(((1R,5S)-6-((5-chloropyridin-2-yloxy)methyl)-3-...)
Affinity DataEC50:  26nMAssay Description:Activity at rat mGluR2 receptor expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343295(2-((4-(2-Methoxy-phenyl)piperidin-1-yl)methyl)-1-m...)
Affinity DataEC50:  951nMAssay Description:Antagonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of quinpirole-induced effectMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343296(4-bromo-5-((4-(2-methoxyphenyl)piperazin-1-yl)meth...)
Affinity DataEC50:  891nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343297(1-methyl-2-((4-(6-methyl-2-(pyrrolidin-1-yl)pyrimi...)
Affinity DataEC50:  4.79E+3nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343295(2-((4-(2-Methoxy-phenyl)piperidin-1-yl)methyl)-1-m...)
Affinity DataEC50:  87nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343298(1-Methyl-2-((4-phenylpiperidin-1-yl)methyl)-1H-ben...)
Affinity DataEC50:  212nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50:  22nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343300(2-((4-(3-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50:  3.31E+3nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343301(2-((4-(4-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50:  159nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343302(2-((4-(2-Chlorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataEC50:  144nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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