Compile Data Set for Download or QSAR
maximum 50k data
Found 596 with Last Name = 'zhang' and Initial = 'yl'
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50029085(CHEBI:83405 | CHEMBL525191 | GDC-0879)
Affinity DataKi:  0.130nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi: <0.200nM ΔG°: <-55.4kJ/mole IC50:  1nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi: <0.200nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219599(5-(3-{[1-(benzylsulfonyl)piperidin-4-yl]amino}phen...)
Affinity DataKi:  0.680nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219588(4-bromo-3-(carboxymethoxy)-5-(3-{[1-({2-[(methylsu...)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi:  1.5nM ΔG°:  -50.4kJ/mole IC50:  13nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19423(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Affinity DataKi:  1.5nMAssay Description:Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219577(5-[3-({1-[(2-aminobenzyl)sulfonyl]piperidin-4-yl}a...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219584(5-{3-[(1-{[2-(acetylamino)benzyl]sulfonyl}piperidi...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219588(4-bromo-3-(carboxymethoxy)-5-(3-{[1-({2-[(methylsu...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219584(5-{3-[(1-{[2-(acetylamino)benzyl]sulfonyl}piperidi...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219577(5-[3-({1-[(2-aminobenzyl)sulfonyl]piperidin-4-yl}a...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219586(4-bromo-3-(carboxymethoxy)-5-{3-[(1-{[2-(trifluoro...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/mole IC50:  2nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219569(4-bromo-3-carboxymethoxy-5-(3-{[1-(2,6-dimethylphe...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219570(4-bromo-3-carboxymethoxy-5-{3-[(1-o-tolylcarbamoyl...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219585(4-bromo-3-carboxymethoxy-5-(3-{[1-(2-methoxyphenyl...)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219566(4-bromo-3-carboxymethoxy-5-[3-(1-phenylmethanesulf...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219567(4-bromo-3-(carboxymethoxy)-5-[3-({1-[(2-methylbenz...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219575(3-carboxymethoxy-5-{3-[1-(2-chlorobenzenesulfonyl)...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219568(4-bromo-3-carboxymethoxy-5-(3-{[1-(2-chlorophenylc...)
Affinity DataKi:  4nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219566(4-bromo-3-carboxymethoxy-5-[3-(1-phenylmethanesulf...)
Affinity DataKi:  5nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219585(4-bromo-3-carboxymethoxy-5-(3-{[1-(2-methoxyphenyl...)
Affinity DataKi:  5nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219570(4-bromo-3-carboxymethoxy-5-{3-[(1-o-tolylcarbamoyl...)
Affinity DataKi:  5nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219575(3-carboxymethoxy-5-{3-[1-(2-chlorobenzenesulfonyl)...)
Affinity DataKi:  5nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219586(4-bromo-3-(carboxymethoxy)-5-{3-[(1-{[2-(trifluoro...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219568(4-bromo-3-carboxymethoxy-5-(3-{[1-(2-chlorophenylc...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219565(4-bromo-3-(carboxymethoxy)-5-[3-({1-[(2,6-dimethyl...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219567(4-bromo-3-(carboxymethoxy)-5-[3-({1-[(2-methylbenz...)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219591(5-[3-({[1-(anilinocarbonyl)piperidin-4-yl]methyl}a...)
Affinity DataKi:  7nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219565(4-bromo-3-(carboxymethoxy)-5-[3-({1-[(2,6-dimethyl...)
Affinity DataKi:  8nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219589(5-(3-{[1-(benzylsulfonyl)piperidin-4-yl]amino}phen...)
Affinity DataKi:  8nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219569(4-bromo-3-carboxymethoxy-5-(3-{[1-(2,6-dimethylphe...)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219576(4-bromo-3-(carboxymethoxy)-5-(3-(1-(3-chlorobenzyl...)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219580(4-bromo-3-(carboxymethoxy)-5-[3-({1-[(4-chlorobenz...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219576(4-bromo-3-(carboxymethoxy)-5-(3-(1-(3-chlorobenzyl...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219583(4-bromo-3-(carboxymethoxy)-5-[3-({1-[(2-{[(ethylam...)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219563(5-(3-{[1-(anilinocarbonyl)piperidin-4-yl]methoxy}p...)
Affinity DataKi:  13nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178095(BRD2492)
Affinity DataKi:  14nM ΔG°:  -44.8kJ/mole IC50:  19nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219583(4-bromo-3-(carboxymethoxy)-5-[3-({1-[(2-{[(ethylam...)
Affinity DataKi:  14nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219581(5-(3-(1-(benzylsulfonyl)piperidin-4-yloxy)phenyl)-...)
Affinity DataKi:  24nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19422(4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-...)
Affinity DataKi:  25nM ΔG°:  -43.4kJ/mole IC50:  46nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219573(4-BROMO-3-(CARBOXYMETHOXY)-5-{3-[(3,3,5,5-TETRAMET...)
Affinity DataKi:  26nMAssay Description:Inhibition of human recombinant TCPTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM178100(BRD3308 | US11377423, Cmpd 1)
Affinity DataKi:  29nM ΔG°:  -43.0kJ/mole IC50:  64nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219573(4-BROMO-3-(CARBOXYMETHOXY)-5-{3-[(3,3,5,5-TETRAMET...)
Affinity DataKi:  36nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Broad Institute of Harvard and Mit

LigandPNGBDBM19422(4-(acetylamino)-N-(2-amino-phenyl) benzamide | CI-...)
Affinity DataKi:  37nM ΔG°:  -42.4kJ/mole IC50:  41nMpH: 7.4 T: 2°CAssay Description:Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219580(4-bromo-3-(carboxymethoxy)-5-[3-({1-[(4-chlorobenz...)
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219596(4-bromo-3-carboxymethoxy-5-[3-(1-methanesulfonylpi...)
Affinity DataKi:  44nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219572(5-[3-(1-benzenesulfonylpiperidin-4-ylamino)phenyl]...)
Affinity DataKi:  55nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50219592(5-[3-({[1-(benzylsulfonyl)piperidin-4-yl]methyl}am...)
Affinity DataKi:  74nMAssay Description:Inhibition of human recombinant PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 596 total ) | Next | Last >>
Jump to: