Compile Data Set for Download or QSAR
maximum 50k data
Found 1442 with Last Name = 'zhang' and Initial = 'zy'
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544441(CHEMBL4637373 | US11192850, Entry 4u)
Affinity DataKi:  1.20nMAssay Description:Competitive inhibition of Mycobacterium tuberculosis PTPB expressed in Escherichia coli BL21 (DE3) using varying levels of p-nitrophenyl phosphate as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50607111(CHEMBL5218807)
Affinity DataKi:  1.20nMAssay Description:Competitive inhibition of LMW-PTP (unknown origin) assessed as inhibition constant by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50379185(CHEMBL1232859)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) cells using p-nitrophenyl phosphate as substrate after 2 to 3 mins by spectrophotometric...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50131550((3S)-3-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1B expressed in human HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544440(CHEMBL4647367 | US11192850, Entry 4t)
Affinity DataKi:  2.70nMAssay Description:Competitive inhibition of Mycobacterium tuberculosis PTPB expressed in Escherichia coli BL21 (DE3) using varying levels of p-nitrophenyl phosphate as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544442(CHEMBL4638011 | US11192850, Entry 4v)
Affinity DataKi:  4.90nMAssay Description:Competitive inhibition of Mycobacterium tuberculosis PTPB expressed in Escherichia coli BL21 (DE3) using varying levels of p-nitrophenyl phosphate as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50436357(CHEMBL2396719)
Affinity DataKi:  110nMAssay Description:Competitive inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50071330(CHEMBL2369450 | c(S-CH2-Ac-Asp-Ala-Asp-Glu-FOMT-Le...)
Affinity DataKi:  170nMAssay Description:Compound was evaluated for the binding affinity against protein-tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50103243(4-{2-[2-(2-Acetylamino-3-carboxy-propionylamino)-p...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50112356(CHEMBL3609373)
Affinity DataKi:  510nMAssay Description:Competitive inhibition of phosphatase activity of SHP2 (unknown origin) using pNPP as a substrate Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558461(CHEMBL4760367)
Affinity DataKi:  1.00E+3nMAssay Description:Competitive inhibition of His-tagged LMW-PTP isoform A (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin-like domain-containing CTD phosphatase 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50087856(CHEMBL3426913)
Affinity DataKi:  1.00E+3nMAssay Description:Competitive inhibition of His6-tagged UBLCP1 (unknown origin) expressed in Escherichia coli BL21 cells by Lineweaver-Burk plot analysis in presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50343142(CHEMBL1773168 | N-(4-butylphenyl)-2-oxo-1,2-dihydr...)
Affinity DataKi:  1.10E+3nMAssay Description:Non-competitive inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB assessed as production of p-nitrophenol from pNPP substrate by L...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558482(CHEMBL4742123)
Affinity DataKi:  1.70E+3nMAssay Description:Competitive inhibition of LMW-PTP isoform B (unknown origin) using para-nitrophenyl phosphate as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50393461(CHEMBL2159938)
Affinity DataKi:  2.16E+3nMAssay Description:Inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50335895(6-hydroxy-3-(1-(4-(naphthalen-1-ylamino)-4-oxobuty...)
Affinity DataKi:  2.90E+3nMAssay Description:Competitive inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50393496(CHEMBL2159935)
Affinity DataKi:  3.07E+3nMAssay Description:Inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50343147(CHEMBL1773180 | N1-(furan-2-ylmethyl)-N2-(1-(4-(4-...)
Affinity DataKi:  3.20E+3nMAssay Description:Competitive inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB assessed as production of p-nitrophenol from pNPP substrate by Linew...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow molecular weight phosphotyrosine protein phosphatase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558482(CHEMBL4742123)
Affinity DataKi:  3.20E+3nMAssay Description:Competitive inhibition of His-tagged LMW-PTP isoform A (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50103235(5-[2-(2-{2-[2-(2-Acetylamino-3-carboxy-propionylam...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50343148(CHEMBL1773181 | N1-(1-(4-(4-fluorophenyl)piperazin...)
Affinity DataKi:  4.00E+3nMAssay Description:Competitive inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB assessed as production of p-nitrophenol from pNPP substrate by Linew...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50348092(CHEMBL1800273)
Affinity DataKi:  4.60E+3nMAssay Description:Competitive inhibition at SHP2 catalytic domain assessed as inhibition of pNPP to p-nitrophenol conversion by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50348092(CHEMBL1800273)
Affinity DataKi:  4.60E+3nMAssay Description:Reversible inhibition at SHP2 catalytic domain assessed as inhibition of pNPP to p-nitrophenol conversion by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1(Homo sapiens (Human))
University Of California San Diego

Curated by ChEMBL
LigandPNGBDBM50585529(CHEMBL5077686)
Affinity DataKi:  4.80E+3nMAssay Description:Covalent inhibition of wild type human SCP1 assessed as inhibition constant using Ac-EDLphosphoSPPSPPLPK-NH2 peptide as substrate preincubated for 0....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308158(3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3...)
Affinity DataKi:  5.20E+3nMAssay Description:Inhibition of SHP2 Src homology-2 domain expressed in Escherichia coli BL21 (DE3) assessed as inhibition of p-nitrophenyl phosphate hydrolysis by Lin...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50432421(CHEMBL2349152)
Affinity DataKi:  5.80E+3nMAssay Description:Non-competitive inhibition of recombinant human PTP1B assessed as inhibition of hydrolysis of pNPP by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50420258(CEFSULODIN)
Affinity DataKi:  6.60E+3nMAssay Description:Competitive inhibition of phosphatase activity of SHP2 (unknown origin) using pNPP as a substrate Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50393463(CHEMBL2159940)
Affinity DataKi:  8.07E+3nMAssay Description:Inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50393461(CHEMBL2159938)
Affinity DataKi:  1.07E+4nMAssay Description:Noncompetitive inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50393462(CHEMBL2159939)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50103240(4-Carbamoyl-4-{[6-(difluoro-phosphono-methyl)-naph...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM46264(3-[2-azaspiro[5.5]undecan-2-yl-(1-cyclopentyl-1,2,...)
Affinity DataKi:  1.25E+4nMAssay Description:Inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50050961(2-{4-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-Acetylamin...)
Affinity DataKi:  1.30E+4nMAssay Description:Compound was evaluated for the binding affinity against protein-tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50132237(CHEMBL320852 | [Difluoro-(6-methanesulfonylaminoca...)
Affinity DataKi:  1.70E+4nMAssay Description:Binding affinity of the compound towards recombinant human Protein-tyrosine phosphatase 1B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50393496(CHEMBL2159935)
Affinity DataKi:  1.76E+4nMAssay Description:Noncompetitive inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50393462(CHEMBL2159939)
Affinity DataKi:  2.13E+4nMAssay Description:Noncompetitive inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50103227(6-(Difluoro-phosphono-methyl)-naphthalene-2-carbox...)
Affinity DataKi:  2.20E+4nMAssay Description:Binding affinity of the compound towards recombinant human Protein-tyrosine phosphatase 1B was determinedMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50103227(6-(Difluoro-phosphono-methyl)-naphthalene-2-carbox...)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50393463(CHEMBL2159940)
Affinity DataKi:  2.39E+4nMAssay Description:Noncompetitive inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50131098(2-(4-{2-((S)-1-(S)-Carbamoyl-3-methyl-butylcarbamo...)
Affinity DataKi:  2.90E+4nMAssay Description:Inhibitory potency against human Protein-tyrosine phosphatase 1B expressed in E. coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50335895(6-hydroxy-3-(1-(4-(naphthalen-1-ylamino)-4-oxobuty...)
Affinity DataKi:  3.39E+4nMAssay Description:Inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM46264(3-[2-azaspiro[5.5]undecan-2-yl-(1-cyclopentyl-1,2,...)
Affinity DataKi:  3.81E+4nMAssay Description:Noncompetitive inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50086645([4-(4-hydroxybenzyl)phenoxy]methylphosphonate)
Affinity DataKi:  4.70E+4nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50379182(CHEMBL289069)
Affinity DataKi:  6.10E+4nMAssay Description:Inhibition of PTP1B expressed in Escherichia coli BL21 (DE3) cells using p-nitrophenyl phosphate as substrate after 2 to 3 mins by spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50075312((Difluoro-naphthalen-2-yl-methyl)-phosphonic acid ...)
Affinity DataKi:  1.79E+5nMAssay Description:Binding affinity of the compound towards recombinant human Protein-tyrosine phosphatase 1B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50103238(3-Carboxymethoxy-naphthalene-2,7-dicarboxylic acid...)
Affinity DataKi:  2.50E+5nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50086647(hydrogen (1-phenanthryloxy)methylphosphonate)
Affinity DataKi:  4.10E+5nMAssay Description:Compound was evaluated for the inhibition constant against Protein-tyrosine phosphatase (PTP1B )More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
New York University

Curated by ChEMBL
LigandPNGBDBM50086647(hydrogen (1-phenanthryloxy)methylphosphonate)
Affinity DataKi:  5.70E+5nMAssay Description:Compound was evaluated for the inhibition constant against dual specificity phosphatase VHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL
LigandPNGBDBM50103234(2-Carboxymethoxy-naphthalene-1,6-dicarboxylic acid...)
Affinity DataKi:  9.00E+5nMAssay Description:Inhibitory activity against human Protein-tyrosinephosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-tyrosine-phosphatase(Yersinia pestis)
Indiana University

Curated by ChEMBL
LigandPNGBDBM26193(2-Hydroxybenzoate, I | 2-hydroxybenzoic acid | CHE...)
Affinity DataKi:  1.00E+6nMAssay Description:Inhibition of Yersinia pseudotuberculosis YopHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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