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Found 165 with Last Name = 'zheng' and Initial = 'd'
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Haisco Pharmaceuticals

US Patent
LigandPNGBDBM633586(N—((S)-1-cyano-2-(3-fluoro-4′-(pentafluoro-1...)
Affinity DataIC50:  0.300nMAssay Description:Recombinant human DPP1 enzyme (R&D Systems, Cat. No. 1071-CY) at a final concentration of 100 μg/mL was mixed with recombinant human cathepsin L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Haisco Pharmaceuticals

US Patent
LigandPNGBDBM633583((S)—N—((S)-1-cyano-2-(2-fluoro-4-(3-(methyl-d3)-2-...)
Affinity DataIC50:  0.5nMAssay Description:Recombinant human DPP1 enzyme (R&D Systems, Cat. No. 1071-CY) at a final concentration of 100 μg/mL was mixed with recombinant human cathepsin L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144428(CHEMBL66159 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Haisco Pharmaceuticals

US Patent
LigandPNGBDBM633575((S)—N—((S)-1-cyano-2-(2-fluoro-4-(3-methyl-2-oxo-2...)
Affinity DataIC50:  1.60nMAssay Description:Recombinant human DPP1 enzyme (R&D Systems, Cat. No. 1071-CY) at a final concentration of 100 μg/mL was mixed with recombinant human cathepsin L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144400(CHEMBL304358 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Haisco Pharmaceuticals

US Patent
LigandPNGBDBM633585(US11807635, Compound 35)
Affinity DataIC50:  4nMAssay Description:Recombinant human DPP1 enzyme (R&D Systems, Cat. No. 1071-CY) at a final concentration of 100 μg/mL was mixed with recombinant human cathepsin L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Haisco Pharmaceuticals

US Patent
LigandPNGBDBM633584((S)—N—((S)-1-cyano-2-(4′-cyano-3-fluoro-3...)
Affinity DataIC50:  4.90nMAssay Description:Recombinant human DPP1 enzyme (R&D Systems, Cat. No. 1071-CY) at a final concentration of 100 μg/mL was mixed with recombinant human cathepsin L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144420(CHEMBL68145 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Haisco Pharmaceuticals

US Patent
LigandPNGBDBM633576((S)—N—((S)-1-cyano-2-(2-fluoro-4-(1-oxo-1,2,3,4-te...)
Affinity DataIC50:  6.70nMAssay Description:Recombinant human DPP1 enzyme (R&D Systems, Cat. No. 1071-CY) at a final concentration of 100 μg/mL was mixed with recombinant human cathepsin L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144428(CHEMBL66159 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144431(CHEMBL303673 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Haisco Pharmaceuticals

US Patent
LigandPNGBDBM633582((S)—N—((S)-1-cyano-2-(4′-cyano-3′-cycl...)
Affinity DataIC50:  7.40nMAssay Description:Recombinant human DPP1 enzyme (R&D Systems, Cat. No. 1071-CY) at a final concentration of 100 μg/mL was mixed with recombinant human cathepsin L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144431(CHEMBL303673 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144396(CHEMBL69375 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144420(CHEMBL68145 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144417(CHEMBL68366 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  9nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50555231(CHEMBL4762103)
Affinity DataIC50:  10nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Haisco Pharmaceuticals

US Patent
LigandPNGBDBM633580((S)—N—((S)-1-cyano-2-(3-fluoro-4′-((4-methyl...)
Affinity DataIC50:  12.9nMAssay Description:Recombinant human DPP1 enzyme (R&D Systems, Cat. No. 1071-CY) at a final concentration of 100 μg/mL was mixed with recombinant human cathepsin L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144417(CHEMBL68366 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144412(CHEMBL69659 | Quinoxaline-2-carboxylic acid [(1S,2...)
Affinity DataIC50:  15nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMajor capsid protein L1(Human papillomavirus type 16)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50089219(CHEMBL3577826)
Affinity DataIC50:  19nMAssay Description:Inhibition of pentamer formation of GST-tagged HPV16 major capsid protein L1 assessed as increased L1-m peak formation incubated with compound after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144421(CHEMBL302533 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Haisco Pharmaceuticals

US Patent
LigandPNGBDBM633578((S)—N—((S)-1-cyano-2-(4-(5-cyano-4-methylthiazol-2...)
Affinity DataIC50:  21nMAssay Description:Recombinant human DPP1 enzyme (R&D Systems, Cat. No. 1071-CY) at a final concentration of 100 μg/mL was mixed with recombinant human cathepsin L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144415(CHEMBL304845 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  22nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50555230(CHEMBL4753446)
Affinity DataIC50:  26nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144393(CHEMBL69274 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  26nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144419(CHEMBL305423 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  27nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144400(CHEMBL304358 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  28nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144400(CHEMBL304358 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  28nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144419(CHEMBL305423 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  31nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Haisco Pharmaceuticals

US Patent
LigandPNGBDBM633581((S)—N—((S)-1-cyano-2-(2-fluoro-4-(4-methylthiazol-...)
Affinity DataIC50:  33nMAssay Description:Recombinant human DPP1 enzyme (R&D Systems, Cat. No. 1071-CY) at a final concentration of 100 μg/mL was mixed with recombinant human cathepsin L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRenin(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144378(5-Chloro-1H-indole-2-carboxylic acid ((1S,2S,4S)-6...)
Affinity DataIC50:  41nMAssay Description:Inhibitory activity of compound against renin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50555224(CHEMBL4790482)
Affinity DataIC50:  46nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144422(CHEMBL308473 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  46nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMajor capsid protein L1(Human papillomavirus type 16)
Jilin University

Curated by ChEMBL
LigandPNGBDBM50089220(CHEMBL3577825)
Affinity DataIC50:  48nMAssay Description:Inhibition of pentamer formation of GST-tagged HPV16 major capsid protein L1 assessed as increased L1-m peak formation incubated with compound after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144404(CHEMBL306685 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  48nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144425(CHEMBL304053 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  52nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144391(CHEMBL68581 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  64nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144422(CHEMBL308473 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  65nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144423(CHEMBL302320 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  68nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Haisco Pharmaceuticals

US Patent
LigandPNGBDBM633579((S)—N—((S)-2-(4-(benzo[d]thiazol-2-yl)-2-fluorophe...)
Affinity DataIC50:  71nMAssay Description:Recombinant human DPP1 enzyme (R&D Systems, Cat. No. 1071-CY) at a final concentration of 100 μg/mL was mixed with recombinant human cathepsin L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144416(CHEMBL69123 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  75nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University For Health Sciences

Curated by ChEMBL
LigandPNGBDBM50461353(CHEMBL4228420)
Affinity DataIC50:  86nMAssay Description:Displacement of [3H]2MeSADP from P2Y12 receptor in human platelets after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144424(CHEMBL306457 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  120nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144416(CHEMBL69123 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  130nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144386(CHEMBL69978 | Quinoline-2-carboxylic acid ((1S,2S,...)
Affinity DataIC50:  130nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50555221(CHEMBL4800434)
Affinity DataIC50:  130nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University For Health Sciences

Curated by ChEMBL
LigandPNGBDBM50461352(CHEMBL4228996)
Affinity DataIC50:  150nMAssay Description:Displacement of [3H]2MeSADP from P2Y12 receptor in human platelets after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144411(CHEMBL71242 | Quinoxaline-2-carboxylic acid [(1S,2...)
Affinity DataIC50:  160nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University For Health Sciences

Curated by ChEMBL
LigandPNGBDBM50461362(CHEMBL4226648)
Affinity DataIC50:  190nMAssay Description:Displacement of [3H]2MeSADP from P2Y12 receptor in human platelets after 60 mins by TopCount scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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