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Found 1758 with Last Name = 'zhong' and Initial = 'm'
TargetCannabinoid receptor 1(Homo sapiens (Human))
Kannalife Sciences

Curated by ChEMBL
LigandPNGBDBM50174316(CHEMBL3809355)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]CP 55940 from human CB1 receptor after 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16292(3-N-[(2S,3S,5R)-3-amino-5-[(4-fluorophenyl)carbamo...)
Affinity DataKi:  26nM ΔG°:  -42.9kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16291(3-N-[(2S,3S,5R)-3-amino-5-{[(1S)-1-(benzylcarbamoy...)
Affinity DataKi:  33nM ΔG°:  -42.3kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Kannalife Sciences

Curated by ChEMBL
LigandPNGBDBM50092588(4-(1,1-Dimethyl-heptyl)-2'-isopropyl-5'-methyl-bip...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]CP 55940 from human CB1 receptor after 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16286(3-N-[(1R,3S,4S)-1-{[(1S)-1-(benzylcarbamoyl)-2-met...)
Affinity DataKi:  71nM ΔG°:  -40.4kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16287(3-N-[(1R,3S,4S)-3-amino-1-{[(1S)-1-(benzylcarbamoy...)
Affinity DataKi:  120nM ΔG°:  -39.1kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50365773(CHEMBL1956552)
Affinity DataKi:  260nMAssay Description:Non-competitive inhibition of Electrophorus electricus AChE assessed as hydrolysis of acetylthiocholineiodide after 15 mins incubation by spectrophot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Kannalife Sciences

Curated by ChEMBL
LigandPNGBDBM50174315(CHEMBL3810140)
Affinity DataKi:  842nMAssay Description:Displacement of [3H]-HU-243 from CB1 receptor in Sabra rat brain synaptosomes after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16289(3-N-[(1R,3S,4S)-1-[(4-fluorophenyl)carbamoyl]-3-hy...)
Affinity DataKi:  1.30E+3nM ΔG°:  -33.3kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16290(3-N-[(1R,3S,4S)-3-amino-1-[(4-fluorophenyl)carbamo...)
Affinity DataKi:  3.00E+3nM ΔG°:  -31.2kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Kannalife Sciences

Curated by ChEMBL
LigandPNGBDBM50318484(2-((1R,6R)-6-Isopropenyl-3-methyl-cyclohex-2-enyl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-HU-243 from CB1 receptor in Sabra rat brain synaptosomes after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16288(3-N-[(1R,3R,4S)-3-amino-1-{[(1S)-1-(benzylcarbamoy...)
Affinity DataKi:  1.13E+4nM ΔG°:  -28.0kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50588044(CHEMBL5176609)
Affinity DataIC50:  1nMAssay Description:Inhibition of BTK (unknown origin) incubated 30 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50522686(CHEMBL4564973)
Affinity DataIC50:  1nMAssay Description:Reversible inhibition of recombinant full-length N-terminal 6-His-tagged human BTK expressed in baculovirus infected Sf21 insect cells using fluoresc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333919((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50333919((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324826((2S)-2-(2,6-dichloro-4-(3-hydroxy-3-(3-hydroxyphen...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of LFA1 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225162((4R)-N-[2-(dimethylamino)ethyl]-1-({4-[(2-phenylbe...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50533659(CHEMBL4444648)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed by baculovirus in Sf21 insect cells measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425864(CHEMBL2312649)
Affinity DataIC50:  2nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStimulator of interferon genes protein [138-378](Mus musculus (Mouse))
Janssen Biotech

US Patent
LigandPNGBDBM501204(US11021511, Compound 4)
Affinity DataIC50: <2nMAssay Description:The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50386338(CHEMBL2048036)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386331(CHEMBL2048028)
Affinity DataIC50:  2.98nMAssay Description:Inhibition of human recombinant ICAM-1 adhesion into human Jurkat cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425870(CHEMBL2311550)
Affinity DataIC50:  3nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386328(CHEMBL2048025)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50353684(CHEMBL1830627)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50386325(CHEMBL2048402)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM348593(US10577374, Compound 316 | US9790229, Compound 316)
Affinity DataIC50:  4nMAssay Description:Inhibition of BTK (unknown origin) incubated 30 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50588005(CHEMBL5199196)
Affinity DataIC50:  4nMAssay Description:Inhibition of BTK (unknown origin) incubated 30 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAurora kinase A(Mus musculus (mouse))
Sunesis Pharmaceuticals

LigandPNGBDBM26333(1-[3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)ph...)
Affinity DataIC50:  4nMpH: 7.2 T: 2°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225163((4R)-1-({4-[(2-chloro-5-fluorobenzene)amido]-3-met...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310621(CHEMBL1079538 | N-(4-(6-(trifluoromethyl)-3H-imida...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50533653(CHEMBL4519741)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed by baculovirus in Sf21 insect cells measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50588037(CHEMBL5198691)
Affinity DataIC50:  5nMAssay Description:Inhibition of BTK (unknown origin) incubated 30 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50588006(CHEMBL5180755)
Affinity DataIC50:  5nMAssay Description:Inhibition of BTK (unknown origin) incubated 30 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Biogen

Curated by ChEMBL
LigandPNGBDBM50588035(CHEMBL5183111)
Affinity DataIC50:  5nMAssay Description:Inhibition of BTK (unknown origin) incubated 30 mins by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324824((S)-2-(2-(benzofuran-2-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50:  5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324822((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50:  5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333915((S)-2-(2-(benzofuran-2-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50:  5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425871(CHEMBL2312651)
Affinity DataIC50:  6nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50533672(CHEMBL4448466)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed by baculovirus in Sf21 insect cells measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310608(CHEMBL1077729 | N-(4-(5-(trifluoromethyl)-1H-benzo...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50533673(CHEMBL4514229)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed by baculovirus in Sf21 insect cells measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50386326(CHEMBL2048024)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50333917((S)-2-(5,7-dichloro-2-(pyrazolo[1,5-a]pyridine-2-c...)
Affinity DataIC50:  7nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50533663(CHEMBL4435097)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed by baculovirus in Sf21 insect cells measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Sichuan University/Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50533677(CHEMBL4435299)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed by baculovirus in Sf21 insect cells measured after 10 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50310607(CHEMBL1078060 | N-(4-(5-chloro-1H-benzo[d]imidazol...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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