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Found 306 with Last Name = 'zhong' and Initial = 's'
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50365773(CHEMBL1956552)
Affinity DataKi:  260nMAssay Description:Non-competitive inhibition of Electrophorus electricus AChE assessed as hydrolysis of acetylthiocholineiodide after 15 mins incubation by spectrophot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
University Of Maryland

Curated by ChEMBL
LigandPNGBDBM22826(2,3-dioxo-2,3-dihydro-1H-indole-7-carboxylic acid ...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human recombinant DNA ligase 1 using nicked DNA substrate by kinetic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  5.00E+3nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  8.00E+3nM IC50:  1.50E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  9.00E+3nM IC50:  2.50E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  1.00E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  1.80E+4nM IC50:  3.60E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  2.10E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  2.50E+4nM IC50:  6.50E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  3.20E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50353684(CHEMBL1830627)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50573585(CHEMBL4846412)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50573586(CHEMBL4867169)
Affinity DataIC50:  4nMAssay Description:Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50573584(CHEMBL4845782)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50573550(CHEMBL4869046)
Affinity DataIC50:  5nMAssay Description:Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM120996(US8716285, 53)
Affinity DataIC50:  12nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50573570(CHEMBL4862483)
Affinity DataIC50:  16nMAssay Description:Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078748(CHEMBL3415629)
Affinity DataIC50:  17nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078747(CHEMBL3415628)
Affinity DataIC50:  18nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50573573(CHEMBL4861661)
Affinity DataIC50:  19nMAssay Description:Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50573569(CHEMBL4862708)
Affinity DataIC50:  20nMAssay Description:Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  21nMAssay Description:Inhibition of equine serum BChE after 15 mins incubation by spectrophotometry based Ellman's methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078695(CHEMBL3415627)
Affinity DataIC50:  21nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  21nMAssay Description:Inhibition of equine serum BChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
TargetCholinesterase(Equus caballus (Horse))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50353680(CHEMBL1830632)
Affinity DataIC50:  21.1nMAssay Description:Inhibition of equine serum BChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50573579(CHEMBL4856653)
Affinity DataIC50:  34nMAssay Description:Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50573580(CHEMBL4866385)
Affinity DataIC50:  36nMAssay Description:Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50353685(CHEMBL1830626)
Affinity DataIC50:  41nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50573574(CHEMBL4858813)
Affinity DataIC50:  46nMAssay Description:Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50:  48nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50573576(CHEMBL4857423)
Affinity DataIC50:  49nMAssay Description:Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death 1 ligand/protein 1(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50573577(CHEMBL4873371)
Affinity DataIC50:  49nMAssay Description:Inhibition of Tag2-PD1/Tag1-PD-L1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50353681(CHEMBL1830631)
Affinity DataIC50:  51.7nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  54nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50353683(CHEMBL1830628)
Affinity DataIC50:  57.1nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50353689(CHEMBL1830630)
Affinity DataIC50:  61nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078687(CHEMBL3415619)
Affinity DataIC50:  63nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50213931(CHEMBL250854 | tylophorinidine)
Affinity DataIC50:  65nMAssay Description:Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50353681(CHEMBL1830631)
Affinity DataIC50:  65nMAssay Description:Inhibition of equine serum BChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50213932(CHEMBL250474 | [(R)-(+)-deoxytylophorinidine)
Affinity DataIC50:  68nMAssay Description:Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078747(CHEMBL3415628)
Affinity DataIC50:  76nMAssay Description:Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50:  80nMAssay Description:Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078680(CHEMBL3415454)
Affinity DataIC50:  90nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078690(CHEMBL3415621)
Affinity DataIC50:  100nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  104nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Equus caballus (Horse))
School Of Chemistry & Chemical Engineering Of Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50353684(CHEMBL1830627)
Affinity DataIC50:  110nMAssay Description:Inhibition of equine serum BChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50213934(CHEMBL398325 | tylophorinine)
Affinity DataIC50:  110nMAssay Description:Inhibition of AP1-mediated gene transcription in HepG2 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078682(CHEMBL3415618)
Affinity DataIC50:  110nMAssay Description:Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078757(CHEMBL3415453)
Affinity DataIC50:  120nMAssay Description:Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078689(CHEMBL3415620)
Affinity DataIC50:  120nMAssay Description:Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac)AMC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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