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Found 27 with Last Name = 'zhu' and Initial = 'jl'
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataIC50:  0.0100nMAssay Description:Displacement of 33-P-S1P from from human S1P receptor expressed in CHO cell membranes after 50 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataIC50:  0.0140nMAssay Description:Displacement of 33-P-S1P from from human S1P receptor expressed in CHO cell membranes after 50 mins by scintillation countingMore data for this Ligand-Target Pair
LigandPNGBDBM50239948(CHEMBL4071326 | US9850225, Example 1166)
Affinity DataIC50:  3nMAssay Description:Inhibition of C-terminal his tagged human PD-1/human Fc tagged PDL-1 interaction expressed in HEK293 cells incubated for 2 hrs AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50362641(CHEMBL384120)
Affinity DataIC50:  250nMAssay Description:Inhibition of his-tagged SARS-COV2 S-RBD binding to C-terminal Fc-tagged human ACE2 expressed in HEK293 cells incubated for 2 hrs by Alphascreen assa...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613798(CHEMBL5267016)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of his-tagged SARS-COV2 S-RBD binding to C-terminal Fc-tagged human ACE2 expressed in HEK293 cells incubated for 2 hrs by Alphascreen assa...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataIC50: >1.00E+3nMAssay Description:Antagonist activity at human S1P3 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50613798(CHEMBL5267016)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of C-terminal his tagged human PD-1/human Fc tagged PDL-1 interaction expressed in HEK293 cells incubated for 2 hrs AlphaScreen assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613799(CHEMBL5283695)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of his-tagged SARS-COV2 S-RBD binding to C-terminal Fc-tagged human ACE2 expressed in HEK293 cells incubated for 2 hrs by Alphascreen assa...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613799(CHEMBL5283695)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of C-terminal his tagged human PD-1/human Fc tagged PDL-1 interaction expressed in HEK293 cells incubated for 2 hrs AlphaScreen assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613800(CHEMBL5282197)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of C-terminal his tagged human PD-1/human Fc tagged PDL-1 interaction expressed in HEK293 cells incubated for 2 hrs AlphaScreen assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613801(CHEMBL5276399)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of his-tagged SARS-COV2 S-RBD binding to C-terminal Fc-tagged human ACE2 expressed in HEK293 cells incubated for 2 hrs by Alphascreen assa...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613800(CHEMBL5282197)
Affinity DataIC50:  6.50E+4nMAssay Description:Inhibition of his-tagged SARS-COV2 S-RBD binding to C-terminal Fc-tagged human ACE2 expressed in HEK293 cells incubated for 2 hrs by Alphascreen assa...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613801(CHEMBL5276399)
Affinity DataIC50:  6.60E+4nMAssay Description:Inhibition of C-terminal his tagged human PD-1/human Fc tagged PDL-1 interaction expressed in HEK293 cells incubated for 2 hrs AlphaScreen assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human S1P3 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataEC50:  0.377nMAssay Description:Agonist activity at human S1P1 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  0.901nMAssay Description:Agonist activity at human S1P1 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataEC50:  0.0700nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells co-expressing GFP assessed as cellular internalization after 45 mins by Hoechst assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  0.114nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells co-expressing GFP assessed as cellular internalization after 45 mins by Hoechst assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataEC50:  0.00560nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as ERK phosphorylation after 7 mins by alphaLISAMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  8.20nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as ERK phosphorylation after 7 mins by alphaLISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataEC50:  0.00500nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by HTRF analysisMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  0.00600nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by HTRF analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human S1P5 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human S1P5 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataEC50:  0.0900nMAssay Description:Agonist activity at human S1P4 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataEC50:  3.60nMAssay Description:Agonist activity at human S1P3 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human S1P4 receptor by GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed