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Found 1252 with Last Name = 'zhu' and Initial = 'k'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM370555((1R,4r)-4-((R)-2-((S)-6-fluoro-5H-imidazo[5,1- a]i...)
Affinity DataKi:  19nMAssay Description:Binding affinity to human IDO1 assessed as inhibition constantMore data for this Ligand-Target Pair
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50606592(CHEMBL5219838)
Affinity DataKi:  280nMAssay Description:Binding affinity to human TDO assessed as inhibition constant by Cornhish-Bowden methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCathepsin B(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503648(CHEMBL4474444)
Affinity DataKi:  340nMAssay Description:Inhibition of cathepsin B (unknown origin) using Z-Arg-Arg-AMC as substrate after 5 mins by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50200540(CHEMBL3972619)
Affinity DataKi:  390nMAssay Description:Binding affinity to human TDO assessed as inhibition constant by Cornhish-Bowden methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503648(CHEMBL4474444)
Affinity DataKi:  720nMAssay Description:Inhibition of cathepsin L (unknown origin) using Z-Phe-Arg-AMC as substrate after 5 mins by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503647(CHEMBL327624)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of cathepsin L (unknown origin) using Z-Phe-Arg-AMC as substrate after 5 mins by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50200540(CHEMBL3972619)
Affinity DataKi:  2.98E+3nMAssay Description:Binding affinity to human IDO1 assessed as inhibition constant by Cornhish-Bowden methodMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50606592(CHEMBL5219838)
Affinity DataKi:  4.48E+3nMAssay Description:Binding affinity to human IDO1 assessed as inhibition constant by Cornhish-Bowden methodMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503647(CHEMBL327624)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of cathepsin B (unknown origin) using Z-Arg-Arg-AMC as substrate after 5 mins by fluorimetric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50207089(D-1-Methyltryptophan | D-1MT | Indoximod)
Affinity DataKi:  1.90E+4nMAssay Description:Binding affinity to human IDO1 assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM24226(1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxypheny...)
Affinity DataKi:  2.30E+4nMAssay Description:Displacement of FITC-labeled EZH2 peptide from recombinant N-terminal 6His-tagged EED (residues 81 to 441) (unknown origin) expressed in Escherichia ...More data for this Ligand-Target Pair
TargetProcathepsin L(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503646(CHEMBL4564457)
Affinity DataKi:  5.90E+4nMAssay Description:Competitive inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured at 1 min interval for 20 mins followed by every 15 mins for 2 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503650(CHEMBL4516952)
Affinity DataKi:  1.46E+5nMAssay Description:Inhibition of human liver cathepsin L using Z-FR-AMC as substrate measured at 1 min interval for 20 mins followed by every 15 mins for 2 hrs by fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50503649(CHEMBL4476113)
Affinity DataKi:  2.00E+5nMAssay Description:Inhibition of KRAS G12C mutant (unknown origin)More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM50462572(CHEMBL4249337)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of full-length human N-terminal FLAG-tagged PRMT5 expressed in Sf9 insect cells using histone H2A as peptide after 120 mins in presence of...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM415557(US10428104, Example 88)
Affinity DataIC50:  1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50285416(CHEMBL4161733)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system using poly (Glu-Tyr) 4:1 as substrate incubated for...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) expressed in baculovirus expression system using poly (Glu-Tyr) 4:1 as substrate incubated for...More data for this Ligand-Target Pair
LigandPNGBDBM653019((M)-1-(6- ((1S,8R)-5- methyl-6-(1,5,6- trimethyl-1...)
Affinity DataIC50:  3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPolycomb protein EED(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50609343(CHEMBL5269445)
Affinity DataIC50:  4.5nMAssay Description:Displacement of H3K27me3 from EED (unknown origin) by competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM652997(1-(6-(3-chloro- 4-(1,6-dimethyl- 1H-indazol-7- yl)...)
Affinity DataIC50:  5nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Wuhan University of Technology

LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  5.90nMpH: 8.0 T: 2°CAssay Description:This spectrophotometric assay is based on the reaction of 5,5-dithio-bis(2-nitrobenzoic)acid (DTNB) with thiocholine to yield a colored product. Sh...More data for this Ligand-Target Pair
LigandPNGBDBM652949((1R,9R)-6-(7- hydroxy-5- quinolinyl)- 10,10-dimeth...)
Affinity DataIC50:  6nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM178166(US10307413, Compound 208 | US10391089, Compound 20...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM178166(US10307413, Compound 208 | US10391089, Compound 20...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H4 as substrate preincubated for 60 mins in presence of enzyme and SAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50562497(CHEMBL4778760)
Affinity DataIC50:  7nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM653472((M)-(7R)-4-(2-methylphenyl)-7-(4- methyl-1,3-thiaz...)
Affinity DataIC50:  8nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM50503687(CHEMBL4465444)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of HDAC1 (unknown origin) using Boc-Lys (Ac)-AMC as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM50529897(CHEMBL4468383)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM652946((P)-(1R,8S)-6- (3-hydroxy-1- naphthalenyl)-4- (2-(...)
Affinity DataIC50:  9nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590774(CHEMBL5203175)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of human TDOMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50:  10nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
LigandPNGBDBM653301(1-(6-((1R,9R)-5-fluoro- 10,10-dimethyl-6-(5- methy...)
Affinity DataIC50:  10nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM653277((1R,9R)-10,10-dimethyl- 6-(6-methyl-1H-indazol- 7-...)
Affinity DataIC50:  11nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM50503688(CHEMBL4545154)
Affinity DataIC50:  11nMAssay Description:Inhibition of HDAC1 (unknown origin) using Boc-Lys (Ac)-AMC as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM50529900(CHEMBL4473655)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM50529901(CHEMBL4568997)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM50529901(CHEMBL4568997)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM50529900(CHEMBL4473655)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM50503686(CHEMBL4449889)
Affinity DataIC50:  12nMAssay Description:Inhibition of HDAC1 (unknown origin) using Boc-Lys (Ac)-AMC as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM653092((7R)-4-(2-chlorophenyl)-7- (1-methyl-1H-pyrazol-5-...)
Affinity DataIC50:  12nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM653165((6R,8R)-2-(2-acryloyl-2,6- diazaspiro[3.4]octan-6-...)
Affinity DataIC50:  12nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM653305((M)-1-(6-((1R,9R)-5- fluoro-6-(3-hydroxy-1- naphth...)
Affinity DataIC50:  13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM50529896(CHEMBL4444027)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM653180((1R,9R)-6-(3-hydroxy-1- naphthalenyl)-10,10- dimet...)
Affinity DataIC50:  13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
University Of Jinan

Curated by ChEMBL
LigandPNGBDBM50529896(CHEMBL4444027)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues)/human N-terminal His-tagged MEP50 (2 to end residues) expressed in H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM653162(7,7-dimethyl-2-(2-(2- propenoyl)-2,6- diazaspiro[3...)
Affinity DataIC50:  13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
LigandPNGBDBM653336((M)-1-(6-(4-(5-chloro- 1,6-dimethyl-1H- indazol-7-...)
Affinity DataIC50:  13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
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