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Found 65 with Last Name = 'zimmerlin' and Initial = 'ag'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research And Novartis Pharma Development

Curated by ChEMBL
LigandPNGBDBM50030448(8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | CHEMBL269732 ...)
Affinity DataIC50:  0.950nMAssay Description:Inhibitory activity against macrophilin (FKBP-12)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research And Novartis Pharma Development

Curated by ChEMBL
LigandPNGBDBM50153090(CHEMBL411735 | Macrolide derivative)
Affinity DataIC50:  1.45nMAssay Description:Inhibitory activity against macrophilin (FKBP-12)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Novartis Institutes For Biomedical Research And Novartis Pharma Development

Curated by ChEMBL
LigandPNGBDBM50153091(CHEMBL265123 | Macrolide derivative)
Affinity DataIC50:  1.88nMAssay Description:Inhibitory activity against macrophilin (FKBP-12)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116037(3,5-Difluoro-4-[5-(4-fluoro-phenyl)-4-pyridin-4-yl...)
Affinity DataIC50:  4nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116031(3,5,6-Trifluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4...)
Affinity DataIC50:  4nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116038(4-(4-Benzofuran-2-yl-5-pyridin-4-yl-1H-imidazol-2-...)
Affinity DataIC50:  5nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116029(3,5-Difluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl...)
Affinity DataIC50:  16nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089127(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089122(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  76nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089123(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116025(2,3,5,6-Tetrafluoro-4-[4-(4-fluoro-phenyl)-5-pyrid...)
Affinity DataIC50:  90nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089125(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089130(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089124(4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-...)
Affinity DataIC50:  130nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116028(3,5-Difluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl...)
Affinity DataIC50:  140nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089132(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089122(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Prostaglandin G/H synthase 1, COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116039(3,5-Difluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl...)
Affinity DataIC50:  210nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089126(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Affinity DataIC50:  350nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116032(3,5-Difluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl...)
Affinity DataIC50:  400nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089131(4-(2-tert-Butyl-5-phenyl-1H-imidazol-4-yl)-pyridin...)
Affinity DataIC50:  450nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089128(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-thiazol-2-yl...)
Affinity DataIC50:  450nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116034(3,5-Difluoro-4-[5-pyridin-4-yl-4-(3-trifluoromethy...)
Affinity DataIC50:  470nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089133(2-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  470nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116027(3,5-Difluoro-4-(4-furan-2-yl-5-pyridin-4-yl-1H-imi...)
Affinity DataIC50:  670nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089126(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Affinity DataIC50:  797nMAssay Description:Inhibition of EGFR kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116024(4-[4-(4-Fluoro-phenyl)-thiazol-5-yl]-pyridine | CH...)
Affinity DataIC50:  800nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116033(2-(4-Fluorophenyl)-3-(pyridin-4-yl)-1H-pyrrole | 4...)
Affinity DataIC50:  800nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50053410(4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole |...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116026(4-[5-(4-Fluoro-phenyl)-2H-[1,2,3]triazol-4-yl]-pyr...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089129(4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-oxazol-2-yl]...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of murine p38 alpha MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116030(3,5,6-Trifluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4...)
Affinity DataIC50:  2.10E+3nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089126(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Affinity DataIC50:  2.41E+3nMAssay Description:Inhibition of human p38 beta MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089123(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Prostaglandin G/H synthase 1, COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089131(4-(2-tert-Butyl-5-phenyl-1H-imidazol-4-yl)-pyridin...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Prostaglandin G/H synthase 1, COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116037(3,5-Difluoro-4-[5-(4-fluoro-phenyl)-4-pyridin-4-yl...)
Affinity DataIC50:  6.30E+3nMAssay Description:In vivo inhibition of ram seminal vesicle Prostaglandin G/H synthase 1 activity by determining PGE-2 by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089130(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of Prostaglandin G/H synthase 1, COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089126(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Affinity DataIC50:  8.09E+3nMAssay Description:Inhibition of JNK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089126(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human p38 delta MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116035(2,3,5,6-Tetrafluoro-4-[4-(4-fluoro-phenyl)-5-pyrid...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vivo inhibition of ram seminal vesicle Prostaglandin G/H synthase 1 activity by determining PGE-2 by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089126(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of JNK1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116035(2,3,5,6-Tetrafluoro-4-[4-(4-fluoro-phenyl)-5-pyrid...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 microM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089126(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089132(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of Prostaglandin G/H synthase 1, COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089126(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Affinity DataIC50:  2.27E+4nMAssay Description:Inhibition of c-src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089127(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of Prostaglandin G/H synthase 1, COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50116039(3,5-Difluoro-4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl...)
Affinity DataIC50:  4.50E+4nMAssay Description:In vivo inhibition of ram seminal vesicle Prostaglandin G/H synthase 1 activity by determining PGE-2 by RIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089126(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Affinity DataIC50:  5.11E+4nMAssay Description:Inhibition of PKCalpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089128(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-thiazol-2-yl...)
Affinity DataIC50:  7.30E+4nMAssay Description:Inhibition of Prostaglandin G/H synthase 1, COX-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Mus musculus)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089126(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Affinity DataIC50:  8.68E+4nMAssay Description:Inhibition of c-abl kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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