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Found 119 with Last Name = 'zimmerman' and Initial = 't'
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM50247677((3S,8S)-14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-...)
Affinity DataKi:  40nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)
Affinity DataKi:  60nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM7461(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)
Affinity DataKi:  110nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM50073099((9E,11E)-(4R,6R,8R)-16-chloro-17,19-dihydroxy-4-me...)
Affinity DataKi:  520nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM50096619(1,8,9-Trihydroxy-3-methoxy-benzo[4,5]furo[3,2-c]ch...)
Affinity DataKi:  600nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM9461(5,7-dihydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one...)
Affinity DataKi:  2.03E+3nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM23419((2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro...)
Affinity DataKi:  3.43E+3nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590870(CHEMBL5170582)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590870(CHEMBL5170582)
Affinity DataIC50:  4nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590866(CHEMBL5187045)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50392999(CHEMBL2152545)
Affinity DataIC50:  6.40nMAssay Description:Pseduo-irreversible inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 30 mins followed by substrate addition and ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590866(CHEMBL5187045)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590863(CHEMBL5179658)
Affinity DataIC50:  13nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590863(CHEMBL5179658)
Affinity DataIC50:  13nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590871(CHEMBL5198516)
Affinity DataIC50:  16nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590871(CHEMBL5198516)
Affinity DataIC50:  16nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590869(CHEMBL5189021)
Affinity DataIC50:  31nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590869(CHEMBL5189021)
Affinity DataIC50:  32nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50392999(CHEMBL2152545)
Affinity DataIC50:  48nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50392999(CHEMBL2152545)
Affinity DataIC50:  50nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590869(CHEMBL5189021)
Affinity DataIC50:  58nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590869(CHEMBL5189021)
Affinity DataIC50:  63nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590864(CHEMBL5170719)
Affinity DataIC50:  77nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590864(CHEMBL5170719)
Affinity DataIC50:  79nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590867(CHEMBL5201804)
Affinity DataIC50:  91nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590867(CHEMBL5201804)
Affinity DataIC50:  100nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590865(CHEMBL5183869)
Affinity DataIC50:  126nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM50282567(3,4-Dichlorophenyl boronic acid | 3,4-dichloro ben...)
Affinity DataIC50:  138nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590865(CHEMBL5183869)
Affinity DataIC50:  139nMAssay Description:Inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590863(CHEMBL5179658)
Affinity DataIC50:  175nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590863(CHEMBL5179658)
Affinity DataIC50:  175nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  188nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM50247677((3S,8S)-14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-...)
Affinity DataIC50:  210nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM92722(Phenylboronic acid, 15)
Affinity DataIC50:  238nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50:  301nMAssay Description:Pseudo-irreversible inhibition of human BChE using butyrylthiocholineiodide as substrate preincubated for 20 to 60 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)
Affinity DataIC50:  400nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM92718(Phenylboronic acid, 10)
Affinity DataIC50:  418nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 1(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM92717(Phenylboronic acid, 8)
Affinity DataIC50:  510nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM26139(1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...)
Affinity DataIC50:  529nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonyl reductase [NADPH] 1(Homo sapiens (Human))
UniversitäT TüBingen

Curated by ChEMBL
LigandPNGBDBM7461(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)
Affinity DataIC50:  670nMAssay Description:Binding affinity to human recombinant carbonyl reductase 1 expressed in Escherichia coli assessed as NADPH oxidation using isatin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590866(CHEMBL5187045)
Affinity DataIC50:  711nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM50590866(CHEMBL5187045)
Affinity DataIC50:  711nMAssay Description:Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcyl-protein thioesterase 1(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM50282567(3,4-Dichlorophenyl boronic acid | 3,4-dichloro ben...)
Affinity DataIC50:  1.10E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 1(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM92718(Phenylboronic acid, 10)
Affinity DataIC50:  1.40E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Julius Maximilian University Of W�Rzburg

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50:  1.50E+3nMAssay Description:Pseudo-irreversible inhibition of human AChE using acetylthiocholineiodide as substrate preincubated for 20 to 60 mins followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM92719(Phenylboronic acid, 12)
Affinity DataIC50:  1.60E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University of Dortmund

LigandPNGBDBM92721(Phenylboronic acid, 14)
Affinity DataIC50:  1.80E+3nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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