BindingDB PrimarySearch_ki

Found 25 with Last Name = 'zuo' and Initial = 'sj'

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

IC50: 1.20nMAssay Description:Inhibition of VEGFR-2 (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)

IC50: 1.30nMAssay Description:Inhibition of wild-type EGFR tyrosine kinase (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)

IC50: 2.60nMAssay Description:Inhibition of EGFR tyrosine kinase L858R mutant (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair

PDB KEGG
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3D Structure (crystal)

Epidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50500089(CHEMBL3740910)

IC50: 4.10nMAssay Description:Inhibition of wild-type EGFR tyrosine kinase (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50500090(CHEMBL3741473)

IC50: 5nMAssay Description:Inhibition of wild-type EGFR tyrosine kinase (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair

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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50233667(CHEMBL4088969)

IC50: 6.70nMAssay Description:Inhibition of P110alpha/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50233666(CHEMBL4097625)

IC50: 7.30nMAssay Description:Inhibition of P110alpha/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Epidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50500088(CHEMBL3740144)

IC50: 8.40nMAssay Description:Inhibition of wild-type EGFR tyrosine kinase (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50500090(CHEMBL3741473)

IC50: 11nMAssay Description:Inhibition of EGFR tyrosine kinase L858R mutant (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair

PDB KEGG
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Epidermal growth factor receptor(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50500089(CHEMBL3740910)

IC50: 12nMAssay Description:Inhibition of EGFR tyrosine kinase L858R mutant (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair

PDB KEGG
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50233667(CHEMBL4088969)

IC50: 21nMAssay Description:Inhibition of P110delta/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50233667(CHEMBL4088969)

IC50: 24nMAssay Description:Inhibition of P110beta/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)

IC50: 89nMAssay Description:Inhibition of P110alpha/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)

IC50: 97nMAssay Description:Inhibition of mTOR (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50233666(CHEMBL4097625)

IC50: 106nMAssay Description:Inhibition of P110delta/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50233667(CHEMBL4088969)

IC50: 114nMAssay Description:Inhibition of mTOR (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50233666(CHEMBL4097625)

IC50: 116nMAssay Description:Inhibition of P110gamma/PIK3R5 (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)

IC50: 169nMAssay Description:Inhibition of P110gamma/PIK3R5 (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50233667(CHEMBL4088969)

IC50: 181nMAssay Description:Inhibition of P110gamma/PIK3R5 (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)

IC50: 204nMAssay Description:Inhibition of P110delta/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50233666(CHEMBL4097625)

IC50: 208nMAssay Description:Inhibition of mTOR (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50233666(CHEMBL4097625)

IC50: 209nMAssay Description:Inhibition of P110beta/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM92862(US9284315, BEZ-235 | mTOR Inhibitor, BEZ235)

IC50: 421nMAssay Description:Inhibition of P110beta/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50500089(CHEMBL3740910)

IC50: 565nMAssay Description:Inhibition of VEGFR-2 (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University

Curated by ChEMBL

PNG

BDBM50500088(CHEMBL3740144)

IC50: >1.00E+3nMAssay Description:Inhibition of VEGFR-2 (unknown origin) assessed as ATP level by luminescence analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

Filter my 25 hits

Targets 7▿
- Epidermal growth factor receptor 7
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 3
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform 3
- Serine/threonine-protein kinase mTOR 3
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5 3
- Vascular endothelial growth factor receptor 2 3
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 3
Publications 2▿
- Bioorg Med Chem 23: 7765-76 (2015) 15
- Bioorg Med Chem 24: 179-90 (2016) 10
Institutions 1▿
- Xi'An Jiaotong University 25
Affinity: 1.2 to 1.0E+3 nM▿
- IC50 25
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 0
Catalog Cmpds: 3