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Found 83 with Last Name = 'de lera' and Initial = 'ar'
TargetHistone deacetylase 1(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50322419(CHEMBL1171466 | Octanethioic acid S-[(E)-4-((5R,8S...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human recombinant HDAC1 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50322418(CHEMBL1173195 | Octanethioic acid S-[(E)-4-((8S,11...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human recombinant HDAC1 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM16241(2,3-dihydroxypropanal | D,L-glyceraldehyde | Glyce...)
Affinity DataIC50:  10nMAssay Description:Inhibition of glyceraldehyde reduction activity of human AKR1B1More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  11.4nMAssay Description:Inhibition of human recombinant HDAC1 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of retinaldehyde reductase activity of human AKR1B10More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50322421(CHEMBL1173194 | Octanethioic acid S-[(E)-4-((5R,8S...)
Affinity DataIC50:  13.7nMAssay Description:Inhibition of human recombinant HDAC1 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447840(BMS-204493 | CHEMBL472172)
Affinity DataIC50:  114nMAssay Description:Inverse agonist activity at RARalpha (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant HDAC1 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50322420(CHEMBL1171465 | Octanethioic acid S-[(E)-4-((5R,8S...)
Affinity DataIC50:  161nMAssay Description:Inhibition of human recombinant HDAC1 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Mus musculus)
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50346143(CHEMBL1783648 | rac-4-[(1E)-3-(7,8-Dihydro-8,8-dim...)
Affinity DataIC50:  400nMAssay Description:Antagonist activity at yeast GAL4 fused mouse RARalpha ligand binding domain expressed in HeLa cells assessed as inhibition of TTNPB-induced receptor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Mus musculus)
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50346144(4-[(1E)-3-(7,8-Dihydro-8,8-dimethyl-5-p-tolylnapht...)
Affinity DataIC50:  400nMAssay Description:Antagonist activity at yeast GAL4 fused mouse RARbeta ligand binding domain expressed in HeLa cells assessed as inhibition of TTNPB-induced receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50211062(3-(hex-5-enyl)-1-{12-[1-(oct-7-enyl)pyridinium-3-y...)
Affinity DataIC50:  530nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50211063(1-(oct-7-enyl)-3-{12-[3-(pent-4-enyl)pyridinium-1-...)
Affinity DataIC50:  540nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of rat AKR1B4More data for this Ligand-Target Pair
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447837(CHEMBL3114297)
Affinity DataIC50:  1.28E+3nMAssay Description:Antagonist activity at Gal4-fused RARalpha (unknown origin) transfected in HEK293 cells assessed as inhibition of ATRA-induced transcriptional activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50211063(1-(oct-7-enyl)-3-{12-[3-(pent-4-enyl)pyridinium-1-...)
Affinity DataIC50:  1.88E+3nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor beta(Mus musculus)
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50346143(CHEMBL1783648 | rac-4-[(1E)-3-(7,8-Dihydro-8,8-dim...)
Affinity DataIC50:  2.00E+3nMAssay Description:Antagonist activity at yeast GAL4 fused mouse RARbeta ligand binding domain expressed in HeLa cells assessed as inhibition of TTNPB-induced receptor ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447838(CHEMBL3114296)
Affinity DataIC50:  2.65E+3nMAssay Description:Antagonist activity at Gal4-fused RARalpha (unknown origin) transfected in HEK293 cells assessed as inhibition of ATRA-induced transcriptional activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50322418(CHEMBL1173195 | Octanethioic acid S-[(E)-4-((8S,11...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant HDAC4 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant HDAC4 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Mus musculus)
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50346146(CHEMBL1783651 | rac-4-[3-(8,8-Dimethyl-5-(phenylet...)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonist activity at yeast GAL4 fused mouse RARgamma ligand binding domain expressed in HeLa cells assessed as inhibition of TTNPB-induced receptor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50322419(CHEMBL1171466 | Octanethioic acid S-[(E)-4-((5R,8S...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant HDAC4 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447838(CHEMBL3114296)
Affinity DataIC50:  3.37E+3nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447835(CHEMBL3114299)
Affinity DataIC50:  4.43E+3nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50244760((E)-4-{3-[3-Adamantan-1-yl-4-(2-methoxy-ethoxymeth...)
Affinity DataIC50:  4.47E+3nMAssay Description:Antagonist activity at Gal4-fused RARalpha (unknown origin) transfected in HEK293 cells assessed as inhibition of ATRA-induced transcriptional activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447839(CHEMBL565088)
Affinity DataIC50:  4.75E+3nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447837(CHEMBL3114297)
Affinity DataIC50:  4.78E+3nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50322420(CHEMBL1171465 | Octanethioic acid S-[(E)-4-((5R,8S...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human recombinant HDAC4 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447836(CHEMBL3114298)
Affinity DataIC50:  5.16E+3nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of human recombinant HDAC4 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50244760((E)-4-{3-[3-Adamantan-1-yl-4-(2-methoxy-ethoxymeth...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of purified recombinant histidine-HA-tagged IKKbeta (unknown origin) expressed in SF9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50293412(6-[5-(Adamant-1-yl)-4-[(2-methoxyethoxy)methoxy]-2...)
Affinity DataIC50:  7.06E+3nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50322421(CHEMBL1173194 | Octanethioic acid S-[(E)-4-((5R,8S...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of human recombinant HDAC4 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447834(CHEMBL3114304)
Affinity DataIC50:  7.81E+3nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Mus musculus)
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50346145(CHEMBL1783649 | rac-4-[(3-(8,8-Dimethyl-5-phenyl-7...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at yeast GAL4 fused mouse RARgamma ligand binding domain expressed in HeLa cells assessed as inhibition of TTNPB-induced receptor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50430056(CHEMBL2336409 | SGI-1027)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of human DNMT1 using AdoMet and poly dI-dC after 2 hrs by radioactive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50244760((E)-4-{3-[3-Adamantan-1-yl-4-(2-methoxy-ethoxymeth...)
Affinity DataIC50:  1.18E+4nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50211062(3-(hex-5-enyl)-1-{12-[1-(oct-7-enyl)pyridinium-3-y...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataKd:  36nMAssay Description:Dissociation constant for binding to Retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Affinity DataKd:  50nMAssay Description:Dissociation constant for binding to Retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50117804((2E,4E)-6-(6-tert-Butyl-1,1-dimethyl-indan-4-yl)-h...)
Affinity DataKd:  220nMAssay Description:Dissociation constant for binding to Retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50101446((2E,4E)-3-Methyl-5-[(1R,2R)-2-methyl-2-(5,5,8,8-te...)
Affinity DataKd:  60nMAssay Description:Dissociation constant for Retinoid X receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50032219((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)
Affinity DataKd:  26nMAssay Description:Dissociation constant for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Affinity DataKd:  0.800nMAssay Description:Dissociation constant for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM31883(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)
Affinity DataKd:  0.200nMAssay Description:Dissociation constant for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50032221(4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)
Affinity DataKd:  32nMAssay Description:Dissociation constant for Retinoid X receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50032221(4-[(E)-2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro...)
Affinity DataKd:  645nMAssay Description:Dissociation constant for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50101445((2E,4E)-3-Methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-te...)
Affinity DataKd:  0.400nMAssay Description:Dissociation constant for Retinoid X receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Affinity DataKd:  1.5nMAssay Description:Dissociation constant for Retinoid X receptor alphaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor gamma(Homo sapiens (Human))
Universidad De Santiago De Compostela

Curated by ChEMBL
LigandPNGBDBM50101445((2E,4E)-3-Methyl-5-[(1S,2S)-2-methyl-2-(5,5,8,8-te...)
Affinity DataKd: >3.00E+4nMAssay Description:Dissociation constant for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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