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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
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Target
Lactoylglutathione lyase
(Homo sapiens (Human))
Sun Yat-Sen University
Curated by
ChEMBL
Ligand
BDBM50012899
((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
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Affinity Data
Ki: 7.79E+4nM
Assay Description:
Inhibition of glyoxalase 1
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Target
Lactoylglutathione lyase
(Homo sapiens (Human))
Sun Yat-Sen University
Curated by
ChEMBL
Ligand
BDBM50012899
((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
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Affinity Data
Ki: 1.39E+5nM
Assay Description:
Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysis
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Target
Aldo-keto reductase family 1 member B1 [K65Q]
(Bos taurus (Cattle))
Comsats Institute of Information Technology
Ligand
BDBM50012899
((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
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Affinity Data
IC50: 293nM
Assay Description:
The activity of ALR2 enzyme was determined at 340 nm in UV spectrophotometer that depends upon the measurement of NADPH consumption. Each well of the...
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Target
Aldo-keto reductase family 1 member B10 [K125R,V301L]
(Homo sapiens (Human))
Institut De Ge??Ne??Tique Et De Biologie Mole??Culaire Et Cellulaire
Ligand
BDBM50012899
((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
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Affinity Data
IC50: 2.69E+3nM
pH: 7.0
Assay Description:
The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...
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Target
Prostaglandin E synthase
(Homo sapiens (Human))
University Of Kentucky
Curated by
ChEMBL
Ligand
BDBM50012899
((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
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Affinity Data
IC50: 8.00E+4nM
Assay Description:
Inhibition of microsomal PGES
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Target
Retinoic acid receptor RXR-alpha
(Homo sapiens (Human))
Xiamen University
Curated by
ChEMBL
Ligand
BDBM50012899
((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
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Affinity Data
IC50: 8.29E+4nM
Assay Description:
Displacement of [3H]-9-cis-RA from RXRalpha (unknown origin) by liquid scintillation counting
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Target
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus)
Warner-Lambert
Curated by
ChEMBL
Ligand
BDBM50012899
((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
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Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of 5-lipoxygenase in intact RBL-1 cell line
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Target
Glycine receptor subunit alpha-1
(Homo sapiens (Human))
University Of Pittsburgh
Curated by
ChEMBL
Ligand
BDBM50012899
((Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl...)
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Affinity Data
EC50: 380nM
Assay Description:
Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...
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