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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
11
hits in this display
Target
Lactoylglutathione lyase
(Homo sapiens (Human))
University Of Maryland
Curated by
ChEMBL
Ligand
BDBM50241121
((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
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Affinity Data
Ki: 80nM
Assay Description:
Inhibition of GLO1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Lactoylglutathione lyase
(Homo sapiens (Human))
University Of Maryland
Curated by
ChEMBL
Ligand
BDBM50241121
((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
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Affinity Data
Ki: 170nM
Assay Description:
Inhibition of Glyoxalase-1 (unknown origin) using GSH and MGO as substrates preincubated with substrates for 6 mins followed by enzyme addition by sp...
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Target
Lactoylglutathione lyase
(Homo sapiens (Human))
University Of Maryland
Curated by
ChEMBL
Ligand
BDBM50241121
((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
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Affinity Data
Ki: 4.30E+3nM
Assay Description:
Compound was evaluated for inhibition of S. cerevisiae glyoxalase-I by using enzymatic assay at each of 6 substrate concentrations between 0.1 mM and...
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Target Info
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GoogleScholar
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CHEMBL
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PubMed
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Target
Lactoylglutathione lyase
(Homo sapiens (Human))
University Of Maryland
Curated by
ChEMBL
Ligand
BDBM50241121
((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
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Affinity Data
Ki: 4.47E+3nM
Assay Description:
Inhibition constant of compound against binding of Yeast Glyoxalase I
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Target
Glyoxalase I
(Saccharomyces cerevisiae)
University Of Minnesota
Curated by
ChEMBL
Ligand
BDBM50241121
((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
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Affinity Data
Ki: 6.28E+3nM
Assay Description:
Inhibition of yeast glyoxalase 1
More data for this Ligand-Target Pair
Target Info
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CHEMBL
KEGG
MMDB
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In Depth
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Article
PubMed
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Target
Lactoylglutathione lyase
(Homo sapiens (Human))
University Of Maryland
Curated by
ChEMBL
Ligand
BDBM50241121
((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 9.14E+3nM
pH: 6.6
Assay Description:
Ability to inhibit yeast glyoxalase I enzyme in 0.05 M phosphate buffer, pH 6.6, 30 degree C
More data for this Ligand-Target Pair
Target Info
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antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
KEGG
MMDB
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lactoylglutathione lyase
(Homo sapiens (Human))
University Of Maryland
Curated by
ChEMBL
Ligand
BDBM50241121
((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
Copy SMILES
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Affinity Data
IC50: 1.20E+3nM
Assay Description:
Inhibition of human recombinant GLO1 expressed in Escherichia coli BL21 assessed as decrease in reduced glutathione level after 1 hr by Ellman's meth...
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
KEGG
MMDB
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lactoylglutathione lyase
(Homo sapiens (Human))
University Of Maryland
Curated by
ChEMBL
Ligand
BDBM50241121
((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8.20E+3nM
Assay Description:
pA2 against human brain adenosine A1 receptor
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
KEGG
MMDB
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lactoylglutathione lyase
(Homo sapiens (Human))
University Of Maryland
Curated by
ChEMBL
Ligand
BDBM50241121
((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.30E+4nM
Assay Description:
Inhibition of human recombinant His-tagged Glyoxalase 1 expressed in Sf21-Baculovirus system
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
KEGG
MMDB
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lactoylglutathione lyase
(Homo sapiens (Human))
University Of Maryland
Curated by
ChEMBL
Ligand
BDBM50241121
((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
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Copy InChI
Affinity Data
IC50: 3.32E+4nM
Assay Description:
Inhibition of human recombinant glyoxalase 1 assessed as S-D-lactoylglutathione after 15 mins by spectrophotometric analysis
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
KEGG
MMDB
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Lactoylglutathione lyase
(Homo sapiens (Human))
University Of Maryland
Curated by
ChEMBL
Ligand
BDBM50241121
((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.32E+4nM
Assay Description:
Inhibition of recombinant human His-tagged glyoxalase 1 expressed in Escherichia coli BL21 assessed as formation of S-D-lactoylglutathione after 5 mi...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
KEGG
MMDB
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI