Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetIntermediate conductance calcium-activated potassium channel protein 4/Potassium voltage-gated channel subfamily E member 1/Potassium voltage-gated channel subfamily KQT member 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50099566((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)Copy SMILESCopy InChI

Affinity DataIC50:  9nMAssay Description:Selectivity for gardos channel; (Gardos channel vs 2000 nM for the cardiac IKs channel).)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetIntermediate conductance calcium-activated potassium channel protein 4(Homo sapiens (Human))
Icagen

Curated by ChEMBL

LigandBDBM50099566((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)Copy SMILESCopy InChI

Affinity DataIC50:  9nMAssay Description:Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] effluxMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50099566((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)Copy SMILESCopy InChI

Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Iks current KvLQT1 potassium channelMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI