Compile Data Set for Download or QSAR
maximum 50k data
Found 11 of ic50 for monomerid = 375544
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of N-terminal GST-fused human full length recombinant MNK2 (1 to 465 residues) expressed in baculovirus-infected Sf21 cells using TATKSGST...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of N-terminal GST-fused human full length recombinant MNK1 (1 to 424 residues) expressed in baculovirus-infected Sf21 cells using TATKSGST...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Affinity DataIC50:  64nMAssay Description:Inhibition of MNK1 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Affinity DataIC50:  64nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Affinity DataIC50:  86nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Affinity DataIC50:  86nMAssay Description:Inhibition of MNK2 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Affinity DataIC50: <100nMAssay Description:MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Affinity DataIC50: <100nMAssay Description:MNK1 and MNK2 inhibitor activity was determined using recombinant kinase domains expressed in E. coli. MNK1 and MNK2 were expressed as GST fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Affinity DataIC50:  321nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition measured after 5 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed