TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 19nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 21nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 21nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 22nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1207,D168A](Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Celgene Avilomics Research
US Patent
Celgene Avilomics Research
US Patent
Affinity DataIC50: 25nMpH: 7.8 T: 2°CAssay Description:The protocol is a modified FRET-based assay (v_02) from In Vitro Resistance Studies of HCV Serine Protease Inhibitors, 2004, JBC, vol. 279, No. 17, p...More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 28nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 28nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 32nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 34nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 39nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 41nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibitory concentration against hepatitis C virus polymeraseMore data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 45nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:HepG2.2.15 cells (Acs et al. Proc Natl Acad Sci USA, 84, (1987), 4641-4), a constitutively HBV-expressing cell line were cultured in DMEM+Glutamax-I ...More data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 57nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibitory concentration of the compound against HCV NS3 protease was determinedMore data for this Ligand-Target Pair
TargetGenome polyprotein [1027-1657](Hepatitis C virus genotype 1a (isolate 1) (HCV))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 61nMpH: 7.5 T: 2°CAssay Description:Inhibition assay using HCV protease.More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair