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Found 314 of ic50 for UniProtKB: P43004
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366648(CHEMBL4173045)
Affinity DataIC50:  17nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50:  17nMAssay Description:Inhibition of EAAT2 (unknown origin) transiently expressed in COS1 cells by [14C]glutamate based uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reduction of [3H]-glutamate uptake after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366648(CHEMBL4173045)
Affinity DataIC50:  17nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366616(CHEMBL4176427)
Affinity DataIC50:  18nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366616(CHEMBL4176427)
Affinity DataIC50:  18nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366614(CHEMBL4176482)
Affinity DataIC50:  36nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366614(CHEMBL4176482)
Affinity DataIC50:  36nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366609(CHEMBL4177507)
Affinity DataIC50:  47nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366609(CHEMBL4177507)
Affinity DataIC50:  47nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410456(CHEMBL2113122)
Affinity DataIC50:  60nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM86712(CAS_868359-05-1 | N-[4-(2-BROMO-4,5-DIFLUOROPHENOX...)
Affinity DataIC50:  71nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM86712(CAS_868359-05-1 | N-[4-(2-BROMO-4,5-DIFLUOROPHENOX...)
Affinity DataIC50:  71nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM86712(CAS_868359-05-1 | N-[4-(2-BROMO-4,5-DIFLUOROPHENOX...)
Affinity DataIC50:  80nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410463(CHEMBL2113115)
Affinity DataIC50:  80nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366656(CHEMBL4162363)
Affinity DataIC50:  84nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366656(CHEMBL4162363)
Affinity DataIC50:  85nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410455(CHEMBL2113116)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM86713(WAY 213394 | WAY-213394)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM86714(WAY 212922 | WAY-212922)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410461(CHEMBL2113126)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410457(CHEMBL2113112)
Affinity DataIC50:  100nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366626(CHEMBL4165811)
Affinity DataIC50:  107nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366626(CHEMBL4165811)
Affinity DataIC50:  110nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410460(CHEMBL2113121)
Affinity DataIC50:  130nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM86712(CAS_868359-05-1 | N-[4-(2-BROMO-4,5-DIFLUOROPHENOX...)
Affinity DataIC50:  130nMAssay Description:Inhibitory concentration against glutamate uptake in oocytes expressing in human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410452(CHEMBL2113125)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50173936(2-Amino-N-(3-methyl-biphenyl-4-yl)-succinamic acid...)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410465(CHEMBL2113113)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410459(CHEMBL2113117)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50561801(CHEMBL4759043)
Affinity DataIC50:  209nMAssay Description:Inhibition of human EAAT2 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50561801(CHEMBL4759043)
Affinity DataIC50:  210nMAssay Description:Inhibition of human EAAT2 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410450(CHEMBL2113118)
Affinity DataIC50:  300nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410453(CHEMBL2113128)
Affinity DataIC50:  300nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410454(CHEMBL2113124)
Affinity DataIC50:  300nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50173917(2-Amino-N-(10-ethyl-10H-phenoxazin-2-yl)-succinami...)
Affinity DataIC50:  300nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50561803(CHEMBL4790691)
Affinity DataIC50:  309nMAssay Description:Inhibition of human EAAT2 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50561803(CHEMBL4790691)
Affinity DataIC50:  310nMAssay Description:Inhibition of human EAAT2 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410458(CHEMBL2113123)
Affinity DataIC50:  400nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366637(CHEMBL4164207)
Affinity DataIC50:  490nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366637(CHEMBL4164207)
Affinity DataIC50:  490nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50197046(CHEMBL3939524)
Affinity DataIC50:  500nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT2 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50173914(2-Amino-N-(3'-chloro-4'-fluoro-6-methyl-biphenyl-3...)
Affinity DataIC50:  500nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410448(CHEMBL2113120)
Affinity DataIC50:  500nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50197046(CHEMBL3939524)
Affinity DataIC50:  501nMAssay Description:Inhibition of [3H]-D-Asp uptake at human EAAT2 expressed in HEK293 cells measured after 3 mins by TopCount methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50410464(CHEMBL2113111)
Affinity DataIC50:  600nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366651(CHEMBL4173825)
Affinity DataIC50:  690nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50366651(CHEMBL4173825)
Affinity DataIC50:  692nMAssay Description:Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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