Found 197 Enz. Inhib. hit(s) with all data for entry = 50009759 
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 39nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
University Of Nottingham
Curated by ChEMBL
University Of Nottingham
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubate...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
University Of Nottingham
Curated by ChEMBL
University Of Nottingham
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of human MLK3 using myelin basic protein as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Of Nottingham
Curated by ChEMBL
University Of Nottingham
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of human PIM1 using KKRNRTLTK as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of human BLK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
Affinity DataIC50: 76nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 81nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 87nMAssay Description:Inhibition of human SYK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
Affinity DataIC50: 91nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 4(Homo sapiens (Human))
University Of Nottingham
Curated by ChEMBL
University Of Nottingham
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of human RIPK4 using histone H2A as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 93nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
University Of Nottingham
Curated by ChEMBL
University Of Nottingham
Curated by ChEMBL
Affinity DataIC50: 96nMAssay Description:Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubate...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
University Of Nottingham
Curated by ChEMBL
University Of Nottingham
Curated by ChEMBL
Affinity DataIC50: 101nMAssay Description:Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubate...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
University Of Nottingham
Curated by ChEMBL
University Of Nottingham
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubate...More data for this Ligand-Target Pair
Affinity DataIC50: 135nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
Affinity DataIC50: 145nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 151nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
University Of Nottingham
Curated by ChEMBL
University Of Nottingham
Curated by ChEMBL
Affinity DataIC50: 168nMAssay Description:Inhibition of human CSF1R using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 174nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
University Of Nottingham
Curated by ChEMBL
University Of Nottingham
Curated by ChEMBL
Affinity DataIC50: 179nMAssay Description:Inhibition of human CAMK1D using KKALRRQETVDAL as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
University Of Nottingham
Curated by ChEMBL
University Of Nottingham
Curated by ChEMBL
Affinity DataIC50: 186nMAssay Description:Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubate...More data for this Ligand-Target Pair
Affinity DataIC50: 191nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 195nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
Affinity DataIC50: 224nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
Affinity DataIC50: 229nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
University Of Nottingham
Curated by ChEMBL
University Of Nottingham
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 245nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 257nMAssay Description:Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureF...More data for this Ligand-Target Pair
Affinity DataIC50: 263nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 269nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
Affinity DataIC50: 275nMAssay Description:Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
Affinity DataIC50: 275nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type 1D(Homo sapiens (Human))
University Of Nottingham
Curated by ChEMBL
University Of Nottingham
Curated by ChEMBL
Affinity DataIC50: 277nMAssay Description:Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubate...More data for this Ligand-Target Pair
