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Found 26 Enz. Inhib. hit(s) with all data for entry = 50030490
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296974(4-((1H-imidazol-1-yl)methyl)phenyl 4-iodobenzenesu...)
Affinity DataIC50:  65.1nMAssay Description:Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50188097(1-(4-Chlorobenzyl)-1H-imidazole | CHEMBL441367)
Affinity DataIC50:  70nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296973(4-((1H-imidazol-1-yl)methyl)phenyl 4-bromobenzenes...)
Affinity DataIC50:  70.4nMAssay Description:Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296970(4-((1H-imidazol-1-yl)methyl)phenyl 4-nitrobenzenes...)
Affinity DataIC50:  85nMAssay Description:Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296972(4-((1H-imidazol-1-yl)methyl)phenyl 4-chlorobenzene...)
Affinity DataIC50:  98.7nMAssay Description:Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296975(4-((1H-imidazol-1-yl)methyl)phenyl 4-methoxybenzen...)
Affinity DataIC50:  101nMAssay Description:Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50188093(1-(4-Nitro-benzyl)-1H-imidazole | 1-(4-nitrobenzyl...)
Affinity DataIC50:  130nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296971(4-((1H-imidazol-1-yl)methyl)phenyl 4-fluorobenzene...)
Affinity DataIC50:  210nMAssay Description:Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296969(4-((1H-imidazol-1-yl)methyl)phenyl 4-methylbenzene...)
Affinity DataIC50:  230nMAssay Description:Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296976(4-((1H-imidazol-1-yl)methyl)phenyl 4-(trifluoromet...)
Affinity DataIC50:  291nMAssay Description:Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50188085(1-(4-Fluorobenzyl)-1H-imidazole | CHEMBL377770)
Affinity DataIC50:  880nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50008733(1-(4-Cyanobenzyl)-1H-imidazole | 4-((1H-imidazol-1...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50188092(1-(4-iodobenzyl)-1H-imidazole | 4-iodobenzyl imida...)
Affinity DataIC50:  1.58E+3nMAssay Description:Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  1.66E+3nMAssay Description:Inhibition of 17,20-lyase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  3.76E+3nMAssay Description:Inhibition of 17alpha-hydroxylase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296973(4-((1H-imidazol-1-yl)methyl)phenyl 4-bromobenzenes...)
Affinity DataIC50:  4.84E+3nMAssay Description:Inhibition of 17alpha-hydroxylase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296975(4-((1H-imidazol-1-yl)methyl)phenyl 4-methoxybenzen...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of 17alpha-hydroxylase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296972(4-((1H-imidazol-1-yl)methyl)phenyl 4-chlorobenzene...)
Affinity DataIC50:  6.85E+3nMAssay Description:Inhibition of 17alpha-hydroxylase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296970(4-((1H-imidazol-1-yl)methyl)phenyl 4-nitrobenzenes...)
Affinity DataIC50:  6.88E+3nMAssay Description:Inhibition of 17alpha-hydroxylase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296974(4-((1H-imidazol-1-yl)methyl)phenyl 4-iodobenzenesu...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of 17alpha-hydroxylase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50188092(1-(4-iodobenzyl)-1H-imidazole | 4-iodobenzyl imida...)
Affinity DataIC50:  1.01E+4nMAssay Description:Inhibition of 17alpha-hydroxylase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296971(4-((1H-imidazol-1-yl)methyl)phenyl 4-fluorobenzene...)
Affinity DataIC50:  1.59E+4nMAssay Description:Inhibition of 17alpha-hydroxylase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50188087(1-(4-methyl-benzyl)-1H-imidazole | 1-(4-methylbenz...)
Affinity DataIC50:  2.45E+4nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296969(4-((1H-imidazol-1-yl)methyl)phenyl 4-methylbenzene...)
Affinity DataIC50:  2.52E+4nMAssay Description:Inhibition of 17alpha-hydroxylase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM50296976(4-((1H-imidazol-1-yl)methyl)phenyl 4-(trifluoromet...)
Affinity DataIC50:  6.49E+4nMAssay Description:Inhibition of 17alpha-hydroxylase activity of rat testicular microsomal P450-17alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
University Of The West Of Scotland

Curated by ChEMBL
LigandPNGBDBM4339((3,4-Dihydroxybenzylidene)malononitrile | 2-[(3,4-...)
Affinity DataIC50:  7.06E+4nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed