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Found 9 Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177786'
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM177786(US9120791, Example 1 | US9120791, Example 38 | US9...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Bcl2 (unknown origin) after 2 hrs by fluorescein-PUMA based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM177786(US9120791, Example 1 | US9120791, Example 38 | US9...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to recombinant wild-type Bcl-2 (unknown origin) using peptide probe incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM177786(US9120791, Example 1 | US9120791, Example 38 | US9...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to recombinant Bcl-2 D103E mutant (unknown origin) using peptide probe incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM177786(US9120791, Example 1 | US9120791, Example 38 | US9...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity to recombinant Bcl-2 D103V mutant (unknown origin) using peptide probe incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM177786(US9120791, Example 1 | US9120791, Example 38 | US9...)
Affinity DataKi:  5.60nMAssay Description:Binding affinity to recombinant Bcl-2 D103Y mutant (unknown origin) using peptide probe incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM177786(US9120791, Example 1 | US9120791, Example 38 | US9...)
Affinity DataIC50:  18nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Les Laboratoires Servier

US Patent
LigandPNGBDBM177786(US9120791, Example 1 | US9120791, Example 38 | US9...)
Affinity DataIC50:  18nMpH: 7.4Assay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM177786(US9120791, Example 1 | US9120791, Example 38 | US9...)
Affinity DataIC50:  21nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Mus musculus (Mouse))
Les Laboratoires Servier

US Patent
LigandPNGBDBM177786(US9120791, Example 1 | US9120791, Example 38 | US9...)
Affinity DataIC50:  21nMpH: 7.4Assay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...More data for this Ligand-Target Pair
In DepthDetails US Patent