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Found 8 Enz. Inhib. hit(s) with Target = 'D(2) dopamine receptor' and Ligand = 'BDBM50057762'
TargetD(2) dopamine receptor(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057762(CHEMBL3323011 | US9598387, Compound 113 | US996974...)
Affinity DataKi:  148nMAssay Description:Displacement of [125I]IABN from chimeric human D2 receptor possessing extracellular loop II of D3 receptor expressed in HEK293 cell membranes by gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057762(CHEMBL3323011 | US9598387, Compound 113 | US996974...)
Affinity DataKi:  511nMAssay Description:The affinities of the target compounds were determined using radioligand binding experiments. All radioligand binding experiments were performed acco...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057762(CHEMBL3323011 | US9598387, Compound 113 | US996974...)
Affinity DataKi:  511nMAssay Description:Displacement of [125I]IABN from human D2LR expressed in HEK293 cell membranes by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057762(CHEMBL3323011 | US9598387, Compound 113 | US996974...)
Affinity DataKi:  511nMAssay Description:Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057762(CHEMBL3323011 | US9598387, Compound 113 | US996974...)
Affinity DataKi:  702nMAssay Description:Displacement of [125I]IABN from wild type human D2R expressed in HEK293 cell membranes by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057762(CHEMBL3323011 | US9598387, Compound 113 | US996974...)
Affinity DataIC50:  111nMAssay Description:Antagonist activity against human D2LR expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057762(CHEMBL3323011 | US9598387, Compound 113 | US996974...)
Affinity DataIC50:  261nMAssay Description:Antagonist activity against human D2LR expressed in CHOK1 cells assessed as inhibition of pergolide-induced beta-arrestin translocation by beta-galac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50057762(CHEMBL3323011 | US9598387, Compound 113 | US996974...)
Affinity DataIC50:  2.30E+3nMAssay Description:Antagonist activity against human D2R expressed in CHO cells assessed as inhibition of quinpirole-induced mitogenesis after 24 hrs by [3H]thymidine u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed