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Found 4 Enz. Inhib. hit(s) with Target = 'DNA polymerase theta' and Ligand = 'BDBM50591248'
TargetDNA polymerase theta(Homo sapiens)
Artios Pharma

Curated by ChEMBL
LigandPNGBDBM50591248(CHEMBL5206992)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of recombinant human full length DNA polymerase theta using DNA substrate measured after 1 hrs in presence of dNTPs by plate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Artios Pharma

Curated by ChEMBL
LigandPNGBDBM50591248(CHEMBL5206992)
Affinity DataIC50: >1.20E+4nMAssay Description:Inhibition of human full length DNA polymerase theta ATPase activity by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Artios Pharma

Curated by ChEMBL
LigandPNGBDBM50591248(CHEMBL5206992)
Affinity DataKd:  6.40nMAssay Description:Displacement of tracer from recombinant Tb-labeled DNA polymerase theta (unknown origin) assessed as end point Kd using DNA as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA polymerase theta(Homo sapiens)
Artios Pharma

Curated by ChEMBL
LigandPNGBDBM50591248(CHEMBL5206992)
Affinity DataKd:  4.80nMAssay Description:Displacement of tracer from recombinant Tb-labeled DNA polymerase theta (unknown origin) using DNA as substrate preincubated for 30 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails PubMed