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Found 5 Enz. Inhib. hit(s) with Target = 'Endothelial lipase' and Ligand = 'BDBM123891'
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123891(US8754113, I-1-85 | US9169240, 24)
Affinity DataIC50:  5nMT: 2°CAssay Description:After the present compound dissolved in DMSO was added to become 0.5% DMSO to the reaction buffer consisting of 20 mM tris hydrochloric acid (pH7.4),...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123891(US8754113, I-1-85 | US9169240, 24)
Affinity DataIC50:  6nMAssay Description:Inhibition of human endothelial lipase using HDL as substrate measured after 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123891(US8754113, I-1-85 | US9169240, 24)
Affinity DataIC50: <10nMpH: 8.0Assay Description:The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123891(US8754113, I-1-85 | US9169240, 24)
Affinity DataIC50:  400nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Shionogi

US Patent
LigandPNGBDBM123891(US8754113, I-1-85 | US9169240, 24)
Affinity DataIC50:  400nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed