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Found 5 Enz. Inhib. hit(s) with Target = 'Estrogen receptor' and Ligand = 'BDBM263707'
TargetEstrogen receptor(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263707(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50:  0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by in cell western assayMore data for this Ligand-Target Pair
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In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263707(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
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TargetEstrogen receptor(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263707(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) expressed in Escherichia coli assessed as inhibition of estrad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263707(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50:  12nMAssay Description:Beta-2 adrenergic receptor antagonistic activity on guinea pig tracheal chainsMore data for this Ligand-Target Pair
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In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263707(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) D538G mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed