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Found 9 Enz. Inhib. hit(s) with Target = 'Induced myeloid leukemia cell differentiation protein Mcl-1' and Ligand = 'BDBM50148863'
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50148863(CHEMBL3769721 | US10533010, Example I-177 | US1120...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of His6-tagged MCL1 (unknown origin) incubated for 0.5 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50148863(CHEMBL3769721 | US10533010, Example I-177 | US1120...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of FITC-Bak-BH3/FITC-Bim-BH3 binding to MCL1 (172 to 327 residues) (unknown origin) expressed in Escherichia coli BL21 CodonPlus (DE3) RIL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50148863(CHEMBL3769721 | US10533010, Example I-177 | US1120...)
Affinity DataKi: <7nMAssay Description:Inhibition of recombinant Mcl-1 (residues 172-327) (unknown origin) using FITC-AHx-GQVGRQLAIIGDDINR-NH2 as substrate after 90 mins by fluorescence po...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50148863(CHEMBL3769721 | US10533010, Example I-177 | US1120...)
Affinity DataKi: <7nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50148863(CHEMBL3769721 | US10533010, Example I-177 | US1120...)
Affinity DataKi: <7nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50148863(CHEMBL3769721 | US10533010, Example I-177 | US1120...)
Affinity DataKi:  8.40nMAssay Description:Inhibition of FITC-Bak-BH3/FITC-Bim-BH3 binding to MCL1 (172 to 327 residues) (unknown origin) expressed in Escherichia coli BL21 CodonPlus (DE3) RIL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50148863(CHEMBL3769721 | US10533010, Example I-177 | US1120...)
Affinity DataKi: <50nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50148863(CHEMBL3769721 | US10533010, Example I-177 | US1120...)
Affinity DataKi: <50nMAssay Description:Inhibition of recombinant Mcl-1 (residues 172-327) (unknown origin) using FITC-AHx-EARIAQELRRIGDEFNETYTR-NH2 as substrate after 90 mins by fluorescen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Hunan University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50148863(CHEMBL3769721 | US10533010, Example I-177 | US1120...)
Affinity DataKi: <50nMAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
In DepthDetails US Patent