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Found 3 Enz. Inhib. hit(s) with Target = 'Kappa-type opioid receptor' and Ligand = 'BDBM50199912'
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

US Patent
LigandPNGBDBM50199912(3-((3S,7R,8R,9alphaR)-2,7,8-trimethyl-3-phenyl-oct...)
Affinity DataKi:  12nM ΔG°:  -45.2kJ/molepH: 7.8 T: 2°CAssay Description:The receptor binding method (DeHaven and DeHaven-Hudkins, 1998) was a modification of the method of Raynor et al. (1994). More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

US Patent
LigandPNGBDBM50199912(3-((3S,7R,8R,9alphaR)-2,7,8-trimethyl-3-phenyl-oct...)
Affinity DataKi:  13nMAssay Description:Antagonist activity assessed as inhibition of U50488-stimulated [35S]GTP-gamma-S binding to human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Adolor

US Patent
LigandPNGBDBM50199912(3-((3S,7R,8R,9alphaR)-2,7,8-trimethyl-3-phenyl-oct...)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity assessed as inhibition of U50488-stimulated [35S]GTP-gamma-S binding to human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed