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Found 3 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase B-raf' and Ligand = 'BDBM333469'
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333469(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-ethoxy-7-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of BRAF V600E mutant-dependent MEK phosphorylation in A375 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333469(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-ethoxy-7-...)
Affinity DataKd: >1.00E+3nMAssay Description:Competition binding assays used herein were developed, validated and performed as described in Fabian et al., Nature Biotechnology 2005, 23, 329-336....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM333469(1-(5-tert- butylisoxazol- 3-yl)-3-(3- (6-ethoxy-7-...)
Affinity DataKd:  67nMAssay Description:Binding affinity to BRAF V600E mutantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed