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Found 5 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase ABL1' and Ligand = 'BDBM445952'
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM445952(US10669246, Example 4 | US10968188, Example 4)
Affinity DataIC50:  4.10nMAssay Description:ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM445952(US10669246, Example 4 | US10968188, Example 4)
Affinity DataIC50:  4.10nMAssay Description:ADP-Glo assay kit was purchased from Promega. Magnesium chloride (MgCl2), bovine serum albumin (BSA), ethylene glycol-bis(β-aminoethyl ether)-N,...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM445952(US10669246, Example 4 | US10968188, Example 4)
Affinity DataIC50:  4.10nMAssay Description:c-abl kinase activity was measured by Promega's ADP-Glo™ Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/μl) is incubated w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM445952(US10669246, Example 4 | US10968188, Example 4)
Affinity DataIC50:  4.10nMAssay Description:c-abl kinase activity was measured by Promega's ADP-Glo™ Assay. In this assay, His-tagged recombinant human ABL1 (0.25 ng/μl) is incubated w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
1St Biotherapeutics

US Patent
LigandPNGBDBM445952(US10669246, Example 4 | US10968188, Example 4)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of recombinant human His-tagged c-Abl kinase assessed as luminescence incubated for 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed